DNA damage-binding protein: Difference between revisions

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<StructureSection load='3ei1' size='350' side='right' caption='Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code [[3ei1]]).' scene='54/541124/Cv/1'>
<StructureSection load='3ei1' size='350' side='right' caption='Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code [[3ei1]]).' scene='54/541124/Cv/1'>
__TOC__
== Function ==
== Function ==


'''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair.  It prevents UV damage to DNA.  <scene name='54/541124/Cv/2'>DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2</scene>.
'''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair.  It prevents UV damage to DNA.  <scene name='54/541124/Cv/2'>DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2</scene>.


DNA in this complex with DDB1 and DDB2 contains modified compounds <scene name='54/541124/Cv/5'>5PY and 64T</scene>, they are derivatives from parent compound THYMIDINE-5'-MONOPHOSPHATE.<ref>PMID:18593899</ref><br />
DNA in this complex with DDB1 and DDB2 contains modified compounds <scene name='54/541124/Cv/5'>5PY and 64T</scene> (in darkmagenta and magenta, respectively), they are derivatives from parent compound THYMIDINE-5'-MONOPHOSPHATE.<ref>PMID:18593899</ref><br /> Water molecules shown as red spheres.


== Disease ==
== Disease ==


Defective activity of DDB2 causes the repair defects in patients with XPE - an autosomal disorder characterized by early onset of cancer and photosensitivity.  
Defective activity of DDB2 causes the repair defects in patients with XPE - an autosomal disorder characterized by early onset of cancer and photosensitivity.  
</StructureSection>
 
== 3D Structures of DNA damage-binding protein ==
== 3D Structures of DNA damage-binding protein ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[DNA damage-binding protein 3D structures]]
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*DDB1
 
**[[2b5l]] – hDDB + simian virus 5 protein – human<br />
**[[2b5m]] – hDDB <br />
**[[2b5m]], [[2b5n]] – hDDB BPB domain<br />
**[[2hye]] – hDDB + simian virus 5 protein + cullin-4A + ring-box protein 1<br />
**[[3e0c]] – hDDB <br />
**[[3i7h]], [[3i7k]], [[3i7l]], [[3i7n]], [[3i7o]], [[3i7p]], [[3i89]], [[3i8c]], [[3i8e]] – hDDB + X protein peptide<br />
**[[4a11]] – hDDB + DNA excision repair protein ERCC-8<br />


*DDB1+DDB2
**[[3ei1]], [[3ei2]], [[4a08]], [[4a09]], [[4a0a]], [[4a0b]], [[4e54]], [[4e5z]] – hDDB + DNA<br />
**[[3ei3]], [[3ei4]] – hDDB <br />
**[[4a0k]] – hDDB + cullin-4A + ring-box protein 1<br />
**[[4a0l]] – hDDB + cullin-4A + ring-box protein 1 + DNA<br />
}}
== References ==
== References ==
<references/>
<references/>
</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]
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