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==CRYSTAL STRUCTURE OF putative mandelate racemase/muconate lactonizing protein from Clostridium beijerinckii NCIMB 8052==
==CRYSTAL STRUCTURE OF putative mandelate racemase/muconate lactonizing protein from Clostridium beijerinckii NCIMB 8052==
<StructureSection load='3gy1' size='340' side='right' caption='[[3gy1]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='3gy1' size='340' side='right'caption='[[3gy1]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3gy1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clob8 Clob8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GY1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GY1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3gy1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_beijerinckii_NCIMB_8052 Clostridium beijerinckii NCIMB 8052]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GY1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cbei_4837 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=290402 CLOB8])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gy1 OCA], [http://pdbe.org/3gy1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gy1 RCSB], [http://www.ebi.ac.uk/pdbsum/3gy1 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3gy1 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gy1 OCA], [https://pdbe.org/3gy1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gy1 RCSB], [https://www.ebi.ac.uk/pdbsum/3gy1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gy1 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3gy1 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IMAND_CLOB8 IMAND_CLOB8]] Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.<ref>PMID:24697546</ref>
[https://www.uniprot.org/uniprot/IMAND_CLOB8 IMAND_CLOB8] Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.<ref>PMID:24697546</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/3gy1_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/3gy1_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Clob8]]
[[Category: Clostridium beijerinckii NCIMB 8052]]
[[Category: Almo, S C]]
[[Category: Large Structures]]
[[Category: Burley, S K]]
[[Category: Almo SC]]
[[Category: Malashkevich, V N]]
[[Category: Burley SK]]
[[Category: Morano, C]]
[[Category: Malashkevich VN]]
[[Category: Structural genomic]]
[[Category: Morano C]]
[[Category: Sauder, J M]]
[[Category: Sauder JM]]
[[Category: Toro, R]]
[[Category: Toro R]]
[[Category: Clostridium beijerinckii ncimb 8052]]
[[Category: Crystal structure]]
[[Category: Enolase]]
[[Category: Isomerase]]
[[Category: Mandelate racemase/muconate lactonizing protein]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
[[Category: PSI, Protein structure initiative]]

Latest revision as of 09:57, 21 February 2024

CRYSTAL STRUCTURE OF putative mandelate racemase/muconate lactonizing protein from Clostridium beijerinckii NCIMB 8052

3gy1, resolution 1.60Å

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