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==CRYSTAL STRUCTURE OF APO E. COLI GTP CYCLOHYDROLASE II==
==CRYSTAL STRUCTURE OF APO E. COLI GTP CYCLOHYDROLASE II==
<StructureSection load='2bz1' size='340' side='right' caption='[[2bz1]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
<StructureSection load='2bz1' size='340' side='right'caption='[[2bz1]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2bz1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BZ1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2bz1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BZ1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAU:2-AMINOETHANESULFONIC+ACID'>TAU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAU:2-AMINOETHANESULFONIC+ACID'>TAU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bz0|2bz0]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz1 OCA], [https://pdbe.org/2bz1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bz1 RCSB], [https://www.ebi.ac.uk/pdbsum/2bz1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bz1 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/GTP_cyclohydrolase_II GTP cyclohydrolase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.25 3.5.4.25] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bz1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bz1 OCA], [http://pdbe.org/2bz1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bz1 RCSB], [http://www.ebi.ac.uk/pdbsum/2bz1 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RIBA_ECOLI RIBA_ECOLI]] Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.<ref>PMID:235552</ref>
[https://www.uniprot.org/uniprot/RIBA_ECOLI RIBA_ECOLI] Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.<ref>PMID:235552</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/2bz1_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/2bz1_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Cyclohydrolase|Cyclohydrolase]]
*[[Cyclohydrolase 3D structures|Cyclohydrolase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: GTP cyclohydrolase II]]
[[Category: Large Structures]]
[[Category: Hawkins, A R]]
[[Category: Hawkins AR]]
[[Category: Kotaka, M]]
[[Category: Kotaka M]]
[[Category: Lamb, H K]]
[[Category: Lamb HK]]
[[Category: Lockyer, M]]
[[Category: Lockyer M]]
[[Category: Ren, J]]
[[Category: Ren J]]
[[Category: Stammers, D K]]
[[Category: Stammers DK]]
[[Category: Catalytic zinc]]
[[Category: Gtp cyclohydrolase ii]]
[[Category: Hydrolase]]
[[Category: Magnesium]]
[[Category: Riboflavin biosynthesis]]
Retrieved from "https://proteopedia.org/2bz1"