2dut: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,329,557 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,329,557 edits
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:
==Crystal structure of a M-loop deletion variant of MENT in the native conformation==
==Crystal structure of a M-loop deletion variant of MENT in the native conformation==
<StructureSection load='2dut' size='340' side='right' caption='[[2dut]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='2dut' size='340' side='right'caption='[[2dut]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2dut]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2h4s 2h4s]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DUT FirstGlance]. <br>
<table><tr><td colspan='2'>[[2dut]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2h4s 2h4s]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DUT FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2h4p|2h4p]], [[2h4r|2h4r]], [[2h4q|2h4q]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MENT-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dut OCA], [https://pdbe.org/2dut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dut RCSB], [https://www.ebi.ac.uk/pdbsum/2dut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dut ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dut OCA], [http://pdbe.org/2dut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dut RCSB], [http://www.ebi.ac.uk/pdbsum/2dut PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SPB10_CHICK SPB10_CHICK]] DNA-binding protein that promotes DNA condensation into transcriptionally inactive heterochromatin in terminally differentiated avian blood cells. Promotes tight packing of nucleosomes into spherical clusters by binding to linker DNA and subsequent oligomerization. Acts as a cysteine protease inhibitor towards CTSL (cathepsin L1) and CTSV (cathepsin L2), but does not inhibit serine proteases.<ref>PMID:10026180</ref> <ref>PMID:11821386</ref> <ref>PMID:12930828</ref> <ref>PMID:16810322</ref> <ref>PMID:9446625</ref>
[https://www.uniprot.org/uniprot/SPB10_CHICK SPB10_CHICK] DNA-binding protein that promotes DNA condensation into transcriptionally inactive heterochromatin in terminally differentiated avian blood cells. Promotes tight packing of nucleosomes into spherical clusters by binding to linker DNA and subsequent oligomerization. Acts as a cysteine protease inhibitor towards CTSL (cathepsin L1) and CTSV (cathepsin L2), but does not inhibit serine proteases.<ref>PMID:10026180</ref> <ref>PMID:11821386</ref> <ref>PMID:12930828</ref> <ref>PMID:16810322</ref> <ref>PMID:9446625</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/du/2dut_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/du/2dut_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 32: Line 32:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chick]]
[[Category: Gallus gallus]]
[[Category: Buckle, A M]]
[[Category: Large Structures]]
[[Category: Irving, J A]]
[[Category: Buckle AM]]
[[Category: McGowan, S]]
[[Category: Irving JA]]
[[Category: Whisstock, J C]]
[[Category: McGowan S]]
[[Category: Hydrolase inhibitor]]
[[Category: Whisstock JC]]
[[Category: Serine protease inhibitor]]
[[Category: Serpin]]
Retrieved from "https://proteopedia.org/2dut"