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==CRYSTAL STRUCTURE OF N-TERMINAL DOMAINS OF HUMAN LA PROTEIN COMPLEXED WITH RNA OLIGOMER AUAUUUU==
 
<StructureSection load='2vod' size='340' side='right' caption='[[2vod]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
==Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAUUUU==
<StructureSection load='2vod' size='340' side='right'caption='[[2vod]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOD FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOD FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s7a|1s7a]], [[1yty|1yty]], [[1zh5|1zh5]], [[1s79|1s79]], [[2voo|2voo]], [[2vop|2vop]], [[2von|2von]], [[1owx|1owx]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [http://pdbe.org/2vod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [http://www.ebi.ac.uk/pdbsum/2vod PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [https://pdbe.org/2vod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [https://www.ebi.ac.uk/pdbsum/2vod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vod ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LA_HUMAN LA_HUMAN] Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.<ref>PMID:3192525</ref> <ref>PMID:2470590</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2vod_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2vod_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Conte, M R]]
[[Category: Large Structures]]
[[Category: Curry, S]]
[[Category: Conte MR]]
[[Category: Kotik-Kogan, O]]
[[Category: Curry S]]
[[Category: Sanfelice, D]]
[[Category: Kotik-Kogan O]]
[[Category: Valentine, E R]]
[[Category: Sanfelice D]]
[[Category: La motif]]
[[Category: Valentine ER]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Rna maturation]]
[[Category: Rna recognition motif]]
[[Category: Rna-binding]]
[[Category: Rna-binding protein]]
[[Category: Systemic lupus erythematosus]]
Retrieved from "https://proteopedia.org/2vod"