1d1k: Difference between revisions

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[[Image:1d1k.gif|left|200px]]


{{Structure
==MUTATED SHIGA-LIKE TOXIN B SUBUNIT (D17E/W34A) COMPLEXED WITH RECEPTOR GB3 ANALOGUE==
|PDB= 1d1k |SIZE=350|CAPTION= <scene name='initialview01'>1d1k</scene>, resolution 2.00&Aring;
<StructureSection load='1d1k' size='340' side='right'caption='[[1d1k]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>
<table><tr><td colspan='2'>[[1d1k]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Phage_h30 Phage h30]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D1K FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1k OCA], [https://pdbe.org/1d1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d1k RCSB], [https://www.ebi.ac.uk/pdbsum/1d1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d1k ProSAT]</span></td></tr>
|RELATEDENTRY=[[1bos|1bos]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d1k OCA], [http://www.ebi.ac.uk/pdbsum/1d1k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d1k RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/STXB_BPH30 STXB_BPH30] The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d1/1d1k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d1k ConSurf].
<div style="clear:both"></div>


'''MUTATED SHIGA-LIKE TOXIN B SUBUNIT (D17E/W34A) COMPLEXED WITH RECEPTOR GB3 ANALOGUE'''
==See Also==
 
*[[Shiga toxin 3D structures|Shiga toxin 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1D1K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1K OCA].
[[Category: Large Structures]]
[[Category: Escherichia coli]]
[[Category: Phage h30]]
[[Category: Single protein]]
[[Category: Brunton JL]]
[[Category: Brunton, J L.]]
[[Category: Ling H]]
[[Category: Ling, H.]]
[[Category: Read RJ]]
[[Category: Read, R J.]]
[[Category: ob-fold]]
[[Category: protein-carbohydrate recognition]]
[[Category: receptor binding]]
[[Category: toxin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:32:44 2008''
Retrieved from "https://proteopedia.org/1d1k"