1d24: Difference between revisions

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[[Image:1d24.jpg|left|200px]]


{{Structure
==CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE==
|PDB= 1d24 |SIZE=350|CAPTION= <scene name='initialview01'>1d24</scene>, resolution 1.900&Aring;
<StructureSection load='1d24' size='340' side='right'caption='[[1d24]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5&#39;-MONOPHOSPHATE'>6OG</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>
<table><tr><td colspan='2'>[[1d24]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D24 FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d24 OCA], [https://pdbe.org/1d24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d24 RCSB], [https://www.ebi.ac.uk/pdbsum/1d24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d24 ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d24 OCA], [http://www.ebi.ac.uk/pdbsum/1d24 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d24 RCSB]</span>
__TOC__
}}
</StructureSection>
 
[[Category: Large Structures]]
'''CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE'''
[[Category: Berman HM]]
 
[[Category: Ginell SL]]
 
[[Category: Jones RA]]
==Overview==
[[Category: Kuzmich S]]
The crystal and molecular structure of the first DNA duplex containing the carcinogenic lesion O6MeG has been determined to a resolution of 1.9 A and refined to an R factor of 19%. (d[CGC-(O6Me)GCG])2 crystallizes in the left-handed Z DNA form and has crystal parameters and conformational features similar to those of the parent sequence [d(CG)3]2. The methyl groups on O6 of G4 and G10 have C5-C6-O6-O6Me torsion angles of 73 degrees and 56 degrees, respectively, and protrude onto the major groove surface. The base-pairing conformation for the methylated G.C base pairs is of the Watson-Crick type as opposed to a wobble-type conformation that had been proposed in a B DNA fragment. As in other Z DNA structures, a spine of hydration is seen in the minor groove.
 
==About this Structure==
1D24 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D24 OCA].
 
==Reference==
Crystal and molecular structure of a DNA duplex containing the carcinogenic lesion O6-methylguanine., Ginell SL, Kuzmich S, Jones RA, Berman HM, Biochemistry. 1990 Nov 20;29(46):10461-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2271657 2271657]
[[Category: Protein complex]]
[[Category: Berman, H M.]]
[[Category: Ginell, S L.]]
[[Category: Jones, R A.]]
[[Category: Kuzmich, S.]]
[[Category: double helix]]
[[Category: modified]]
[[Category: z-dna]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:33:06 2008''

Latest revision as of 06:48, 7 February 2024

CRYSTAL AND MOLECULAR STRUCTURE OF A DNA DUPLEX CONTAINING THE CARCINOGENIC LESION O6-METHYLGUANINE

1d24, resolution 1.90Å

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