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==Crystal structure of the fosfomycin resistance protein from transposon Tn2921==
==Crystal structure of the fosfomycin resistance protein from transposon Tn2921==
<StructureSection load='1npb' size='340' side='right' caption='[[1npb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1npb' size='340' side='right'caption='[[1npb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1npb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus marcescens" (bizio 1823) trevisan in de toni and trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NPB FirstGlance]. <br>
<table><tr><td colspan='2'>[[1npb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NPB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TN2921 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=615 "Bacillus marcescens" (Bizio 1823) Trevisan in de Toni and Trevisan 1889])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1npb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npb OCA], [http://pdbe.org/1npb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1npb RCSB], [http://www.ebi.ac.uk/pdbsum/1npb PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1npb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npb OCA], [https://pdbe.org/1npb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1npb RCSB], [https://www.ebi.ac.uk/pdbsum/1npb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1npb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FOSA_SERMA FOSA_SERMA]] Metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin.<ref>PMID:9115979</ref>
[https://www.uniprot.org/uniprot/FOSA_SERMA FOSA_SERMA] Metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin.<ref>PMID:9115979</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/1npb_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/1npb_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Armstrong, R N]]
[[Category: Large Structures]]
[[Category: Newcomer, M E]]
[[Category: Serratia marcescens]]
[[Category: Pakhomova, S]]
[[Category: Armstrong RN]]
[[Category: Rife, C L]]
[[Category: Newcomer ME]]
[[Category: Manganese binding]]
[[Category: Pakhomova S]]
[[Category: Potassium binding loop]]
[[Category: Rife CL]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/1npb"