2wbb: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1-PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR== | |||
<StructureSection load='2wbb' size='340' side='right' caption='[[2wbb]], [[Resolution|resolution]] 2.22Å' scene=''> | ==FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR== | ||
<StructureSection load='2wbb' size='340' side='right'caption='[[2wbb]], [[Resolution|resolution]] 2.22Å' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2wbb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WBB FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RO3:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE'>RO3</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbb OCA], [https://pdbe.org/2wbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wbb RCSB], [https://www.ebi.ac.uk/pdbsum/2wbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbb ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wbb_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wbb_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 31: | Line 33: | ||
==See Also== | ==See Also== | ||
*[[Fructose-1%2C6-bisphosphatase|Fructose-1%2C6-bisphosphatase]] | *[[Fructose-1%2C6-bisphosphatase 3D structures|Fructose-1%2C6-bisphosphatase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Benz | [[Category: Alvarez Sanchez R]] | ||
[[Category: Bernadeau | [[Category: Benz J]] | ||
[[Category: Fol | [[Category: Bernadeau A]] | ||
[[Category: Gubler | [[Category: Fol B]] | ||
[[Category: Haap | [[Category: Gubler M]] | ||
[[Category: Hebeisen | [[Category: Haap W]] | ||
[[Category: Huber | [[Category: Hebeisen P]] | ||
[[Category: Joseph | [[Category: Huber W]] | ||
[[Category: Kitas | [[Category: Joseph C]] | ||
[[Category: Kuhn | [[Category: Kitas E]] | ||
[[Category: Mohr | [[Category: Kuhn B]] | ||
[[Category: Paehler | [[Category: Mohr P]] | ||
[[Category: Ruf | [[Category: Paehler A]] | ||
[[Category: Ruf A]] | |||
[[Category: Schott | [[Category: Schott B]] | ||
[[Category: Tetaz | [[Category: Tetaz T]] | ||
[[Category: Tozzo | [[Category: Tozzo E]] | ||
[[Category: Wessel | [[Category: Wessel HP]] | ||
Latest revision as of 15:50, 13 December 2023
FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR
| ||||||||||||
