2iyf: Difference between revisions
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==The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering== | ==The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering== | ||
<StructureSection load='2iyf' size='340' side='right' caption='[[2iyf]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2iyf' size='340' side='right'caption='[[2iyf]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2iyf]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2iyf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IYF FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ERY:ERYTHROMYCIN+A'>ERY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ERY:ERYTHROMYCIN+A'>ERY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyf OCA], [https://pdbe.org/2iyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iyf RCSB], [https://www.ebi.ac.uk/pdbsum/2iyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyf ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/OLED_STRAT OLED_STRAT] Specifically inactivates oleandomycin via 2'-O-glycosylation using UDP-glucose. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iy/2iyf_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iy/2iyf_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
*[[Glycosyltransferase|Glycosyltransferase]] | *[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bolam | [[Category: Streptomyces antibioticus]] | ||
[[Category: Davies | [[Category: Bolam DN]] | ||
[[Category: Davis | [[Category: Davies GJ]] | ||
[[Category: Dodson | [[Category: Davis BG]] | ||
[[Category: Gilbert | [[Category: Dodson EJ]] | ||
[[Category: Martinez-Fleites | [[Category: Gilbert HJ]] | ||
[[Category: Proctor | [[Category: Martinez-Fleites C]] | ||
[[Category: Roberts | [[Category: Proctor MR]] | ||
[[Category: Turkenburg | [[Category: Roberts SM]] | ||
[[Category: Yang | [[Category: Turkenburg JP]] | ||
[[Category: Yang M]] | |||
Latest revision as of 09:32, 9 May 2024
The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering
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