2rcy: Difference between revisions

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==Crystal structure of Plasmodium falciparum pyrroline carboxylate reductase (MAL13P1.284) with NADP bound==
==Crystal structure of Plasmodium falciparum pyrroline carboxylate reductase (MAL13P1.284) with NADP bound==
<StructureSection load='2rcy' size='340' side='right' caption='[[2rcy]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2rcy' size='340' side='right'caption='[[2rcy]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2rcy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RCY FirstGlance]. <br>
<table><tr><td colspan='2'>[[2rcy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RCY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAL13P1.284 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rcy OCA], [https://pdbe.org/2rcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rcy RCSB], [https://www.ebi.ac.uk/pdbsum/2rcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rcy ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyrroline-5-carboxylate_reductase Pyrroline-5-carboxylate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.2 1.5.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rcy OCA], [http://pdbe.org/2rcy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rcy RCSB], [http://www.ebi.ac.uk/pdbsum/2rcy PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8IDC6_PLAF7 Q8IDC6_PLAF7]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/2rcy_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/2rcy_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Plaf7]]
[[Category: Large Structures]]
[[Category: Pyrroline-5-carboxylate reductase]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Amani, M]]
[[Category: Amani M]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Artz, J D]]
[[Category: Artz JD]]
[[Category: Bochkarev, A]]
[[Category: Bochkarev A]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Hassanali, A]]
[[Category: Hassanali A]]
[[Category: Hui, R]]
[[Category: Hui R]]
[[Category: Khuu, C]]
[[Category: Khuu C]]
[[Category: Kozieradzki, I]]
[[Category: Kozieradzki I]]
[[Category: Lew, J]]
[[Category: Lew J]]
[[Category: Lin, Y H]]
[[Category: Lin YH]]
[[Category: Ren, H]]
[[Category: Ren H]]
[[Category: Structural genomic]]
[[Category: Schapira M]]
[[Category: Schapira, M]]
[[Category: Sun X]]
[[Category: Sun, X]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M]]
[[Category: Wasney G]]
[[Category: Wasney, G]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Wernimont AK]]
[[Category: Wernimont, A K]]
[[Category: Zhao Y]]
[[Category: Zhao, Y]]
[[Category: Malaria]]
[[Category: Oxidoreductase]]
[[Category: Pyrroline reductase]]
[[Category: Sgc]]
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