2vtx: Difference between revisions
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==ACTIVATION OF NUCLEOPLASMIN, AN OLIGOMERIC HISTONE CHAPERONE, CHALLENGES ITS STABILITY== | ==ACTIVATION OF NUCLEOPLASMIN, AN OLIGOMERIC HISTONE CHAPERONE, CHALLENGES ITS STABILITY== | ||
<StructureSection load='2vtx' size='340' side='right' caption='[[2vtx]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='2vtx' size='340' side='right'caption='[[2vtx]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vtx]] is a 10 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2vtx]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VTX FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vtx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vtx OCA], [https://pdbe.org/2vtx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vtx RCSB], [https://www.ebi.ac.uk/pdbsum/2vtx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vtx ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/NUPL_XENLA NUPL_XENLA] Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Nucleoplasmin is an acidic protein which is able to assemble nucleosomes by binding histones and transferring them to DNA. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vt/2vtx_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vt/2vtx_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arregi | [[Category: Xenopus laevis]] | ||
[[Category: Banuelos | [[Category: Arregi I]] | ||
[[Category: Falces | [[Category: Banuelos S]] | ||
[[Category: Franco | [[Category: Falces J]] | ||
[[Category: Montoya | [[Category: Franco G]] | ||
[[Category: Muga | [[Category: Montoya G]] | ||
[[Category: Munoz | [[Category: Muga A]] | ||
[[Category: Taneva | [[Category: Munoz IG]] | ||
[[Category: Urbaneja | [[Category: Taneva SG]] | ||
[[Category: Urbaneja MA]] | |||
