3i90: Difference between revisions
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==Crystal structure of human chromobox homolog 6 (CBX6) with H3K27 peptide== | ==Crystal structure of human chromobox homolog 6 (CBX6) with H3K27 peptide== | ||
<StructureSection load='3i90' size='340' side='right' caption='[[3i90]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3i90' size='340' side='right'caption='[[3i90]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3i90]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3i90]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I90 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i90 OCA], [https://pdbe.org/3i90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i90 RCSB], [https://www.ebi.ac.uk/pdbsum/3i90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i90 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CBX6_HUMAN CBX6_HUMAN] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.<ref>PMID:21282530</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i9/3i90_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i9/3i90_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 33: | Line 33: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Amaya | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Amaya MF]] | ||
[[Category: Bochkarev | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Bochkarev A]] | ||
[[Category: Edwards | [[Category: Bountra C]] | ||
[[Category: Kozieradzki | [[Category: Edwards AM]] | ||
[[Category: Loppnau | [[Category: Kozieradzki I]] | ||
[[Category: Min | [[Category: Loppnau P]] | ||
[[Category: Ouyang | [[Category: Min J]] | ||
[[Category: Ravichandran | [[Category: Ouyang H]] | ||
[[Category: Ravichandran M]] | |||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
