1eem: Difference between revisions

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==GLUTATHIONE TRANSFERASE FROM HOMO SAPIENS==
==GLUTATHIONE TRANSFERASE FROM HOMO SAPIENS==
<StructureSection load='1eem' size='340' side='right' caption='[[1eem]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='1eem' size='340' side='right'caption='[[1eem]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1eem]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EEM FirstGlance]. <br>
<table><tr><td colspan='2'>[[1eem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EEM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eem OCA], [http://pdbe.org/1eem PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1eem RCSB], [http://www.ebi.ac.uk/pdbsum/1eem PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eem OCA], [https://pdbe.org/1eem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eem RCSB], [https://www.ebi.ac.uk/pdbsum/1eem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eem ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GSTO1_HUMAN GSTO1_HUMAN]] Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.<ref>PMID:10783391</ref> <ref>PMID:11511179</ref> <ref>PMID:17226937</ref> <ref>PMID:18028863</ref> <ref>PMID:21106529</ref>
[https://www.uniprot.org/uniprot/GSTO1_HUMAN GSTO1_HUMAN] Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.<ref>PMID:10783391</ref> <ref>PMID:11511179</ref> <ref>PMID:17226937</ref> <ref>PMID:18028863</ref> <ref>PMID:21106529</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ee/1eem_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ee/1eem_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Glutathione S-transferase|Glutathione S-transferase]]
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Board, P]]
[[Category: Large Structures]]
[[Category: Chelvanayagam, G]]
[[Category: Board P]]
[[Category: Chrunyk, B A]]
[[Category: Chelvanayagam G]]
[[Category: Coggan, M]]
[[Category: Chrunyk BA]]
[[Category: Danley, D E]]
[[Category: Coggan M]]
[[Category: Easteal, S]]
[[Category: Danley DE]]
[[Category: Gabel, C A]]
[[Category: Easteal S]]
[[Category: Geoghegan, K F]]
[[Category: Gabel CA]]
[[Category: Griffor, M C]]
[[Category: Geoghegan KF]]
[[Category: Hoth, L R]]
[[Category: Griffor MC]]
[[Category: Jermiin, L S]]
[[Category: Hoth LR]]
[[Category: Kamath, A V]]
[[Category: Jermiin LS]]
[[Category: Pandit, J]]
[[Category: Kamath AV]]
[[Category: Perregaux, D E]]
[[Category: Pandit J]]
[[Category: Rosner, M H]]
[[Category: Perregaux DE]]
[[Category: Schulte, G K]]
[[Category: Rosner MH]]
[[Category: Glutathione conjugating]]
[[Category: Schulte GK]]
[[Category: Gst]]
[[Category: Putative oxidoreductase]]
[[Category: Transferase]]