2fw3: Difference between revisions

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==Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326==
==Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326==
<StructureSection load='2fw3' size='340' side='right' caption='[[2fw3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2fw3' size='340' side='right'caption='[[2fw3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2fw3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FW3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2fw3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FW3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BUI:(3R)-3-{[(TETRADECYLAMINO)CARBONYL]AMINO}-4-(TRIMETHYLAMMONIO)BUTANOATE'>BUI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BUI:(3R)-3-{[(TETRADECYLAMINO)CARBONYL]AMINO}-4-(TRIMETHYLAMMONIO)BUTANOATE'>BUI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fw3 OCA], [http://pdbe.org/2fw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fw3 RCSB], [http://www.ebi.ac.uk/pdbsum/2fw3 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fw3 OCA], [https://pdbe.org/2fw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fw3 RCSB], [https://www.ebi.ac.uk/pdbsum/2fw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fw3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CPT2_RAT CPT2_RAT]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/2fw3_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/2fw3_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fw3 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fw3 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.
A monotopic membrane protein goes solo.,Mattevi A Structure. 2006 Apr;14(4):628-9. PMID:16615901<ref>PMID:16615901</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2fw3" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Carnitine palmitoyltransferase|Carnitine palmitoyltransferase]]
*[[Carnitine palmitoyltransferase|Carnitine palmitoyltransferase]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Carnitine O-palmitoyltransferase]]
[[Category: Rattus norvegicus]]
[[Category: Banner, D W]]
[[Category: Banner DW]]
[[Category: Benz, J]]
[[Category: Benz J]]
[[Category: Chomienne, O]]
[[Category: Chomienne O]]
[[Category: Gsell, B]]
[[Category: De Roo E]]
[[Category: Hennig, M]]
[[Category: Gsell B]]
[[Category: Mueller, F]]
[[Category: Hennig M]]
[[Category: Roo, E De]]
[[Category: Mueller F]]
[[Category: Rufer, A C]]
[[Category: Rufer AC]]
[[Category: Stihle, M]]
[[Category: Stihle M]]
[[Category: Thoma, R]]
[[Category: Thoma R]]
[[Category: Central six-stranded beta-sheet]]
[[Category: Transferase]]
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