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==STRUCTURE AND FUNCTION OF THE B/HLH/Z DOMAIN OF USF==
==STRUCTURE AND FUNCTION OF THE B/HLH/Z DOMAIN OF USF==
<StructureSection load='1an4' size='340' side='right' caption='[[1an4]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='1an4' size='340' side='right'caption='[[1an4]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1an4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AN4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1an4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AN4 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1an4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1an4 OCA], [http://pdbe.org/1an4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1an4 RCSB], [http://www.ebi.ac.uk/pdbsum/1an4 PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1an4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1an4 OCA], [https://pdbe.org/1an4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1an4 RCSB], [https://www.ebi.ac.uk/pdbsum/1an4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1an4 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/USF1_HUMAN USF1_HUMAN]] Genetic variations in USF1 are associated with hyperlipidemia combined type 1 (HYPLIP1) [MIM:[http://omim.org/entry/602491 602491]]; also known as familial combined hyperlipidemia type 1 (FCHL1). HYPLIP1 is characterized by elevated levels of serum total cholesterol, triglycerides or both, and is observed in about 20% of individuals with premature coronary heart disease.<ref>PMID:14991056</ref>
[https://www.uniprot.org/uniprot/USF1_HUMAN USF1_HUMAN] Genetic variations in USF1 are associated with hyperlipidemia combined type 1 (HYPLIP1) [MIM:[https://omim.org/entry/602491 602491]; also known as familial combined hyperlipidemia type 1 (FCHL1). HYPLIP1 is characterized by elevated levels of serum total cholesterol, triglycerides or both, and is observed in about 20% of individuals with premature coronary heart disease.<ref>PMID:14991056</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/USF1_HUMAN USF1_HUMAN]] Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.  
[https://www.uniprot.org/uniprot/USF1_HUMAN USF1_HUMAN] Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/1an4_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/1an4_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Amare, A R.Ferre-D]]
[[Category: Large Structures]]
[[Category: Burley, S K]]
[[Category: Burley SK]]
[[Category: Pognonec, P]]
[[Category: Ferre-D'Amare AR]]
[[Category: Roeder, R G]]
[[Category: Pognonec P]]
[[Category: Double helix]]
[[Category: Roeder RG]]
[[Category: Overhanging base]]
[[Category: Protein-dna complex]]
[[Category: Transcription-dna complex]]
Retrieved from "https://proteopedia.org/1an4"