2fcb: Difference between revisions

<StructureSection load='2fcb' size='340' side='right'caption='[[2fcb]], [[Resolution|resolution]] 1.74&Aring;' scene=''>

<table><tr><td colspan='2'>[[2fcb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FCB FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fcb OCA], [https://pdbe.org/2fcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fcb RCSB], [https://www.ebi.ac.uk/pdbsum/2fcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fcb ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/FCG2B_HUMAN FCG2B_HUMAN] Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.  Defects in FCGR2B are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:[https://omim.org/entry/152700 152700]. A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.<ref>PMID:12115230</ref> <ref>PMID:20385827</ref>  

[https://www.uniprot.org/uniprot/FCG2B_HUMAN FCG2B_HUMAN] Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/2fcb_consurf.spt"</scriptWhenChecked>

     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Huber R]]

[[Category: Jacob U]]

[[Category: Sondermann P]]