1gn0: Difference between revisions

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==Escherichia coli GlpE sulfurtransferase soaked with KCN==
==Escherichia coli GlpE sulfurtransferase soaked with KCN==
<StructureSection load='1gn0' size='340' side='right' caption='[[1gn0]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='1gn0' size='340' side='right'caption='[[1gn0]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1gn0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecobd Ecobd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GN0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1gn0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GN0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gmx|1gmx]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiosulfate_sulfurtransferase Thiosulfate sulfurtransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.1 2.8.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gn0 OCA], [https://pdbe.org/1gn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gn0 RCSB], [https://www.ebi.ac.uk/pdbsum/1gn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gn0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gn0 OCA], [http://pdbe.org/1gn0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gn0 RCSB], [http://www.ebi.ac.uk/pdbsum/1gn0 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GLPE_ECOLI GLPE_ECOLI]] Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. The relatively low affinity of GlpE for both thiosulfate and cyanide suggests that these compounds are not the physiological substrates. Thioredoxin 1 or related dithiol proteins could instead be the physiological sulfur-acceptor substrate. Possible association with the metabolism of glycerol-phosphate remains to be elucidated.[HAMAP-Rule:MF_01009]  
[https://www.uniprot.org/uniprot/GLPE_ECOLI GLPE_ECOLI] Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. The relatively low affinity of GlpE for both thiosulfate and cyanide suggests that these compounds are not the physiological substrates. Thioredoxin 1 or related dithiol proteins could instead be the physiological sulfur-acceptor substrate. Possible association with the metabolism of glycerol-phosphate remains to be elucidated.[HAMAP-Rule:MF_01009]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/1gn0_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/1gn0_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecobd]]
[[Category: Large Structures]]
[[Category: Thiosulfate sulfurtransferase]]
[[Category: Bolognesi M]]
[[Category: Bolognesi, M]]
[[Category: Bordo D]]
[[Category: Bordo, D]]
[[Category: Donahue JT]]
[[Category: Donahue, J T]]
[[Category: Larson TJ]]
[[Category: Larson, T J]]
[[Category: Spallarossa A]]
[[Category: Spallarossa, A]]
[[Category: Glycerol metabolism]]
[[Category: Rhodanese]]
[[Category: Sulfurtransferase]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/1gn0"