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==Crystal Structure Analysis of Fungal Versatile Peroxidase from Pleurotus eryngii==
==Crystal Structure Analysis of Fungal Versatile Peroxidase from Pleurotus eryngii==
<StructureSection load='3fm4' size='340' side='right' caption='[[3fm4]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
<StructureSection load='3fm4' size='340' side='right'caption='[[3fm4]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3fm4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Boletus_of_the_steppes Boletus of the steppes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FM4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FM4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3fm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pleurotus_eryngii Pleurotus eryngii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FM4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2boq|2boq]], [[3fjw|3fjw]], [[3fkg|3fkg]], [[3fm1|3fm1]], [[3fm6|3fm6]], [[3fmu|3fmu]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VPL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5323 Boletus of the steppes])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fm4 OCA], [https://pdbe.org/3fm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fm4 RCSB], [https://www.ebi.ac.uk/pdbsum/3fm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fm4 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Versatile_peroxidase Versatile peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.16 1.11.1.16] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fm4 OCA], [http://pdbe.org/3fm4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fm4 RCSB], [http://www.ebi.ac.uk/pdbsum/3fm4 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VPL2_PLEER VPL2_PLEER]] A versatile ligninolytic peroxidase that combines the substrate specificity characteristics of the two other ligninolytic peroxidases, manganese peroxidase and lignin peroxidase.<ref>PMID:9987124</ref>
[https://www.uniprot.org/uniprot/VPL2_PLEER VPL2_PLEER] A versatile ligninolytic peroxidase that combines the substrate specificity characteristics of the two other ligninolytic peroxidases, manganese peroxidase and lignin peroxidase.<ref>PMID:9987124</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/3fm4_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/3fm4_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Boletus of the steppes]]
[[Category: Large Structures]]
[[Category: Versatile peroxidase]]
[[Category: Pleurotus eryngii]]
[[Category: Choinowski, T]]
[[Category: Choinowski T]]
[[Category: Martinez, A T]]
[[Category: Martinez AT]]
[[Category: Piontek, K]]
[[Category: Piontek K]]
[[Category: Plattner, D A]]
[[Category: Plattner DA]]
[[Category: Electron transfer]]
[[Category: Heme]]
[[Category: Hydrogen peroxide]]
[[Category: Iron]]
[[Category: Lignin degradation]]
[[Category: Lignin peroxidase]]
[[Category: Manganese]]
[[Category: Manganese peroxidase]]
[[Category: Metal-binding]]
[[Category: Mn-independent oxidation phenolic non-phenolic aromatic]]
[[Category: Mnii oxidation]]
[[Category: Oxidoreductase]]
[[Category: Peroxidase]]
[[Category: Polyvalent peroxidase]]
[[Category: Protoporphyrin ix]]
[[Category: Secreted]]
[[Category: Zymogen]]

Latest revision as of 09:18, 13 August 2026

Crystal Structure Analysis of Fungal Versatile Peroxidase from Pleurotus eryngii

3fm4, resolution 2.11Å

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