1e8k: Difference between revisions

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[[Image:1e8k.gif|left|200px]]


{{Structure
==Cyclophilin 3 Complexed With Dipeptide Ala-Pro==
|PDB= 1e8k |SIZE=350|CAPTION= <scene name='initialview01'>1e8k</scene>, resolution 1.90&Aring;
<StructureSection load='1e8k' size='340' side='right'caption='[[1e8k]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE= <scene name='pdbsite=CBS:Cyclosporin+Binding+Site'>CBS</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ALA:ALANINE'>ALA</scene>
<table><tr><td colspan='2'>[[1e8k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E8K FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8k OCA], [https://pdbe.org/1e8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e8k RCSB], [https://www.ebi.ac.uk/pdbsum/1e8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e8k ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8k OCA], [http://www.ebi.ac.uk/pdbsum/1e8k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e8k RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/CYP3_CAEEL CYP3_CAEEL] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/1e8k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e8k ConSurf].
<div style="clear:both"></div>


'''CYCLOPHILIN 3 COMPLEXED WITH DIPEPTIDE ALA-PRO'''
==See Also==
 
*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1E8K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8K OCA].
 
==Reference==
The First Direct Determination of a Ligand Binding Constant in Protein Crystals., Wu Sy S, Dornan J, Kontopidis G, Taylor P, Walkinshaw MD, Angew Chem Int Ed Engl. 2001 Feb 2;40(3):582-586. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11180378 11180378]
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Dornan, J.]]
[[Category: Dornan J]]
[[Category: Kontopidis, G.]]
[[Category: Kontopidis G]]
[[Category: Taylor, P.]]
[[Category: Taylor P]]
[[Category: Walkinshaw, M D.]]
[[Category: Walkinshaw MD]]
[[Category: Wu, S Y.]]
[[Category: Wu SY]]
[[Category: isomerase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:57:28 2008''
Retrieved from "https://proteopedia.org/1e8k"