3ix6: Difference between revisions

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==Crystal structure of Thymidylate synthase thyA from Brucella melitensis==
==Crystal structure of Thymidylate synthase thyA from Brucella melitensis==
<StructureSection load='3ix6' size='340' side='right' caption='[[3ix6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3ix6' size='340' side='right'caption='[[3ix6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ix6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_melitensis"_(hughes_1893)_bruce_1893 "micrococcus melitensis" (hughes 1893) bruce 1893]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IX6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ix6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_melitensis Brucella melitensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IX6 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">thyA, BMEI0608 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29459 "Micrococcus melitensis" (Hughes 1893) Bruce 1893])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ix6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix6 OCA], [https://pdbe.org/3ix6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ix6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ix6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ix6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ix6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix6 OCA], [http://pdbe.org/3ix6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ix6 RCSB], [http://www.ebi.ac.uk/pdbsum/3ix6 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TYSY_BRUME TYSY_BRUME]] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).  
[https://www.uniprot.org/uniprot/TYSY_BRUME TYSY_BRUME] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ix6_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ix6_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Thymidylate synthase|Thymidylate synthase]]
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Thymidylate synthase]]
[[Category: Brucella melitensis]]
[[Category: Structural genomic]]
[[Category: Large Structures]]
[[Category: Brucellosis]]
[[Category: Epididymitis]]
[[Category: Mastitis]]
[[Category: Methyltransferase]]
[[Category: Niaid]]
[[Category: Nucleotide biosynthesis]]
[[Category: Orchitis]]
[[Category: Seattle structural center for infectious disease]]
[[Category: Ssgcid]]
[[Category: Thymidylate]]
[[Category: Transferase]]

Latest revision as of 10:07, 21 February 2024

Crystal structure of Thymidylate synthase thyA from Brucella melitensis

3ix6, resolution 2.20Å

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