2wft: Difference between revisions
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== | |||
<StructureSection load='2wft' size='340' side='right' caption='[[2wft]], [[Resolution|resolution]] 2.80Å' scene=''> | ==Crystal structure of the human HIP ectodomain== | ||
<StructureSection load='2wft' size='340' side='right'caption='[[2wft]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wft]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2wft]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WFT FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wfx|2wfx]], [[2wg4|2wg4]], [[2wg3|2wg3]], [[2wfq|2wfq]], [[2wfr|2wfr]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wfx|2wfx]], [[2wg4|2wg4]], [[2wg3|2wg3]], [[2wfq|2wfq]], [[2wfr|2wfr]]</div></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wft OCA], [https://pdbe.org/2wft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wft RCSB], [https://www.ebi.ac.uk/pdbsum/2wft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wft ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/HHIP_HUMAN HHIP_HUMAN]] Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.<ref>PMID:11472839</ref> <ref>PMID:19561609</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wft_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wft_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 33: | Line 34: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Aricescu, A R]] | [[Category: Aricescu, A R]] | ||
[[Category: Bishop, B]] | [[Category: Bishop, B]] | ||
| Line 39: | Line 41: | ||
[[Category: Jones, E Y]] | [[Category: Jones, E Y]] | ||
[[Category: Siebold, C]] | [[Category: Siebold, C]] | ||
[[Category: Alternative splicing]] | |||
[[Category: Cell membrane]] | [[Category: Cell membrane]] | ||
[[Category: Cytoplasm]] | |||
[[Category: Development]] | [[Category: Development]] | ||
[[Category: Disulfide bond]] | [[Category: Disulfide bond]] | ||
| Line 46: | Line 50: | ||
[[Category: Hedgehog signalling]] | [[Category: Hedgehog signalling]] | ||
[[Category: Membrane]] | [[Category: Membrane]] | ||
[[Category: Polymorphism]] | |||
[[Category: Secreted]] | [[Category: Secreted]] | ||
[[Category: Signal transduction]] | [[Category: Signal transduction]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
Latest revision as of 11:06, 6 April 2022
Crystal structure of the human HIP ectodomain
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