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[[Image:1ewm.jpg|left|200px]]


{{Structure
==THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-112==
|PDB= 1ewm |SIZE=350|CAPTION= <scene name='initialview01'>1ewm</scene>, resolution 2.00&Aring;
<StructureSection load='1ewm' size='340' side='right'caption='[[1ewm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=RL2:N-[3-CARBOXY-2-HYDROXY-PROPIONYL]-L-HOMOPHENYLALANYL-AMINO-2-METHYLBUTANE'>RL2</scene>
<table><tr><td colspan='2'>[[1ewm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EWM FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RL2:N-[3-CARBOXY-2-HYDROXY-PROPIONYL]-L-HOMOPHENYLALANYL-AMINO-2-METHYLBUTANE'>RL2</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ewm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ewm OCA], [https://pdbe.org/1ewm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ewm RCSB], [https://www.ebi.ac.uk/pdbsum/1ewm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ewm ProSAT]</span></td></tr>
|RELATEDENTRY=[[1aim|1aim]], [[2aim|2aim]], [[1ewl|1ewl]], [[1ewo|1ewo]], [[1ewp|1ewp]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ewm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ewm OCA], [http://www.ebi.ac.uk/pdbsum/1ewm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ewm RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group.  The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/1ewm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ewm ConSurf].
<div style="clear:both"></div>


'''THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-112'''
==See Also==
 
*[[Cruzain|Cruzain]]
 
__TOC__
==About this Structure==
</StructureSection>
1EWM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWM OCA].
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
[[Category: Brinen, L S.]]
[[Category: Brinen LS]]
[[Category: Fletterick, R J.]]
[[Category: Fletterick RJ]]
[[Category: Gillmor, S A.]]
[[Category: Gillmor SA]]
[[Category: covalent inhibitor]]
[[Category: cruzain]]
[[Category: cruzipain]]
[[Category: cysteine protease]]
[[Category: drug design]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:11:06 2008''
Retrieved from "https://proteopedia.org/1ewm"