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==Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate==
==Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate==
<StructureSection load='3cc9' size='340' side='right' caption='[[3cc9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3cc9' size='340' side='right'caption='[[3cc9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3cc9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plavs Plavs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CC9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3cc9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax_Sal-1 Plasmodium vivax Sal-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CC9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF11_0295, PVX_092040 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=126793 PLAVS])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cc9 OCA], [http://pdbe.org/3cc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cc9 RCSB], [http://www.ebi.ac.uk/pdbsum/3cc9 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cc9 OCA], [https://pdbe.org/3cc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cc9 RCSB], [https://www.ebi.ac.uk/pdbsum/3cc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cc9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A5K4U6_PLAVS A5K4U6_PLAVS]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/3cc9_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/3cc9_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Plavs]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Plasmodium vivax Sal-1]]
[[Category: Artz, J D]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A]]
[[Category: Artz JD]]
[[Category: Bountra, C]]
[[Category: Bochkarev A]]
[[Category: Cossar, D]]
[[Category: Bountra C]]
[[Category: Dunford, J]]
[[Category: Cossar D]]
[[Category: Edwards, A M]]
[[Category: Dunford J]]
[[Category: Hui, R]]
[[Category: Edwards AM]]
[[Category: Kozieradzki, I]]
[[Category: Hui R]]
[[Category: Lew, J]]
[[Category: Kozieradzki I]]
[[Category: Structural genomic]]
[[Category: Lew J]]
[[Category: Schapira, M]]
[[Category: Schapira M]]
[[Category: Weigelt, J]]
[[Category: Weigelt J]]
[[Category: Wernimont, A K]]
[[Category: Wernimont AK]]
[[Category: Zhao, Y]]
[[Category: Zhao Y]]
[[Category: Farnesyl pyrophosphate synthase diphosphate]]
[[Category: Lyase]]
[[Category: Malaria]]
[[Category: Sgc]]

Latest revision as of 12:25, 30 August 2023

Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate

3cc9, resolution 2.30Å

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