1c72: Difference between revisions

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==TYR115, GLN165 AND TRP209 CONTRIBUTE TO THE 1,2-EPOXY-3-(P-NITROPHENOXY)PROPANE CONJUGATING ACTIVITIES OF GLUTATHIONE S-TRANSFERASE CGSTM1-1==
==TYR115, GLN165 AND TRP209 CONTRIBUTE TO THE 1,2-EPOXY-3-(P-NITROPHENOXY)PROPANE CONJUGATING ACTIVITIES OF GLUTATHIONE S-TRANSFERASE CGSTM1-1==
<StructureSection load='1c72' size='340' side='right' caption='[[1c72]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='1c72' size='340' side='right'caption='[[1c72]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1c72]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C72 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C72 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1c72]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C72 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPY:1-HYDROXY-2-S-GLUTATHIONYL-3-PARA-NITROPHENOXY-PROPANE'>EPY</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPY:1-HYDROXY-2-S-GLUTATHIONYL-3-PARA-NITROPHENOXY-PROPANE'>EPY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c72 OCA], [http://pdbe.org/1c72 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1c72 RCSB], [http://www.ebi.ac.uk/pdbsum/1c72 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c72 OCA], [https://pdbe.org/1c72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c72 RCSB], [https://www.ebi.ac.uk/pdbsum/1c72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c72 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GSTM2_CHICK GSTM2_CHICK]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.  
[https://www.uniprot.org/uniprot/GSTM2_CHICK GSTM2_CHICK] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/1c72_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/1c72_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Glutathione S-transferase|Glutathione S-transferase]]
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chick]]
[[Category: Gallus gallus]]
[[Category: Glutathione transferase]]
[[Category: Large Structures]]
[[Category: Chern, M K]]
[[Category: Chern MK]]
[[Category: Chou, C C]]
[[Category: Chou CC]]
[[Category: Hsiao, C D]]
[[Category: Hsiao CD]]
[[Category: Hsieh, C H]]
[[Category: Hsieh CH]]
[[Category: Kuan, I C]]
[[Category: Kuan IC]]
[[Category: Liu, L F]]
[[Category: Liu LF]]
[[Category: Tam, M F]]
[[Category: Tam MF]]
[[Category: Wu, T C]]
[[Category: Wu TC]]
[[Category: Yeh, Y H]]
[[Category: Yeh YH]]
[[Category: Epoxidase activity]]
[[Category: Glutathione s-transferase]]
[[Category: Steady-state kinetic]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/1c72"