3hk6: Difference between revisions

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==Crystal structure of murine thrombin mutant W215A/E217A (two molecules in the asymmetric unit)==
==Crystal structure of murine thrombin mutant W215A/E217A (two molecules in the asymmetric unit)==
<StructureSection load='3hk6' size='340' side='right' caption='[[3hk6]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='3hk6' size='340' side='right'caption='[[3hk6]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3hk6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HK6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3hk6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HK6 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tq0|1tq0]], [[3hk3|3hk3]], [[3hki|3hki]], [[3hkj|3hkj]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">F2, Cf2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hk6 OCA], [https://pdbe.org/3hk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hk6 RCSB], [https://www.ebi.ac.uk/pdbsum/3hk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hk6 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hk6 OCA], [http://pdbe.org/3hk6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hk6 RCSB], [http://www.ebi.ac.uk/pdbsum/3hk6 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/THRB_MOUSE THRB_MOUSE]] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).  
[https://www.uniprot.org/uniprot/THRB_MOUSE THRB_MOUSE] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/3hk6_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/3hk6_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Thrombin|Thrombin]]
*[[Thrombin 3D Structures|Thrombin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Thrombin]]
[[Category: Mus musculus]]
[[Category: Bush-Pelc, L]]
[[Category: Bush-Pelc L]]
[[Category: Cera, E Di]]
[[Category: Chen Z]]
[[Category: Chen, Z]]
[[Category: Di Cera E]]
[[Category: Gandhi, P S]]
[[Category: Gandhi PS]]
[[Category: Page, M J]]
[[Category: Page MJ]]
[[Category: Acute phase]]
[[Category: Blood coagulation]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Disulfide bond]]
[[Category: Gamma-carboxyglutamic acid]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Kringle]]
[[Category: Protease]]
[[Category: Serine protease]]
[[Category: Zymogen]]
Retrieved from "https://proteopedia.org/3hk6"