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==Crystal structure of an immunity protein that contributes to the self-protection of bacteriocin-producing Enterococcus mundtii 15-1A==
==Crystal structure of an immunity protein that contributes to the self-protection of bacteriocin-producing Enterococcus mundtii 15-1A==
<StructureSection load='2zrr' size='340' side='right' caption='[[2zrr]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2zrr' size='340' side='right'caption='[[2zrr]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2zrr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43186 Atcc 43186]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZRR FirstGlance]. <br>
<table><tr><td colspan='2'>[[2zrr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_mundtii Enterococcus mundtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZRR FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">orf8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53346 ATCC 43186])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zrr OCA], [http://pdbe.org/2zrr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zrr RCSB], [http://www.ebi.ac.uk/pdbsum/2zrr PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zrr OCA], [https://pdbe.org/2zrr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zrr RCSB], [https://www.ebi.ac.uk/pdbsum/2zrr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zrr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B9A7V6_ENTMU B9A7V6_ENTMU]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/2zrr_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/2zrr_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 16: Line 19:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zrr ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zrr ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bacteriocin-producing lactic acid bacteria (LAB) possess a self-protection factor, which is generally called an immunity protein. In this study, we determine the crystal structure of an immunity protein, designated Mun-im, which was classified into subgroup B immunity proteins for class IIa bacteriocins. The Mun-im protein takes a left-turning antiparallel four-helix bundle structure with the flexible N- and C-terminal parts. Although the amino acid sequences of the subgroup B immunity proteins are distinguished from those of the subgroup A, the core structure of Mun-im is well-superimposed with that of the subgroup A immunity protein, EntA-im, and the C-terminus of both proteins is flexible. However, the C-terminus of Mun-im is obviously shorter than that of the subgroup A. We found through mutagenic study of Mun-im that the C-terminus and the K86 residue on the helix 4 in the immunity protein molecule are important for expression of the immunity activity on the subgroup B immunity proteins.
Crystal structure and mutagenic analysis of a bacteriocin immunity protein, Mun-im.,Jeon HJ, Noda M, Matoba Y, Kumagai T, Sugiyama M Biochem Biophys Res Commun. 2009 Jan 16;378(3):574-8. Epub 2008 Dec 4. PMID:19061861<ref>PMID:19061861</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2zrr" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 43186]]
[[Category: Enterococcus mundtii]]
[[Category: Jeon, H J]]
[[Category: Large Structures]]
[[Category: Kumagai, T]]
[[Category: Jeon HJ]]
[[Category: Matoba, Y]]
[[Category: Kumagai T]]
[[Category: Noda, M]]
[[Category: Matoba Y]]
[[Category: Sugiyama, M]]
[[Category: Noda M]]
[[Category: Antimicrobial protein]]
[[Category: Sugiyama M]]
[[Category: Antiparallel four-helix bundle]]
Retrieved from "https://proteopedia.org/2zrr"