2vt8: Difference between revisions
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==Structure of a conserved dimerisation domain within Fbox7 and PI31== | ==Structure of a conserved dimerisation domain within Fbox7 and PI31== | ||
<StructureSection load='2vt8' size='340' side='right' caption='[[2vt8]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='2vt8' size='340' side='right'caption='[[2vt8]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vt8]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2vt8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VT8 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vt8 OCA], [https://pdbe.org/2vt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vt8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vt8 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PSMF1_HUMAN PSMF1_HUMAN] Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.<ref>PMID:10764772</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vt/2vt8_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vt/2vt8_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Kirk | [[Category: Large Structures]] | ||
[[Category: Knowles | [[Category: Kirk RJ]] | ||
[[Category: Laman | [[Category: Knowles PP]] | ||
[[Category: | [[Category: Laman H]] | ||
[[Category: Murray-Rust | [[Category: McDonald NQ]] | ||
[[Category: Murray-Rust J]] | |||
Latest revision as of 01:27, 21 November 2024
Structure of a conserved dimerisation domain within Fbox7 and PI31
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