2o2f: Difference between revisions
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==Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand== | ==Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand== | ||
<StructureSection load='2o2f' size='340' side='right' caption='[[2o2f | <StructureSection load='2o2f' size='340' side='right'caption='[[2o2f]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2o2f]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2o2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2F FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LI0:4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE'>LI0</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LI0:4-(4-BENZYL-4-METHOXYPIPERIDIN-1-YL)-N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]BENZAMIDE'>LI0</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2f OCA], [https://pdbe.org/2o2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2f RCSB], [https://www.ebi.ac.uk/pdbsum/2o2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2f ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o2f_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o2f_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
*[[ | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Belli | [[Category: Large Structures]] | ||
[[Category: Bruncko | [[Category: Belli BA]] | ||
[[Category: Ding | [[Category: Bruncko M]] | ||
[[Category: Elmore | [[Category: Ding H]] | ||
[[Category: Fesik | [[Category: Elmore SW]] | ||
[[Category: Joseph | [[Category: Fesik SW]] | ||
[[Category: Kunzer | [[Category: Joseph MK]] | ||
[[Category: Martineau | [[Category: Kunzer A]] | ||
[[Category: McClellan | [[Category: Martineau D]] | ||
[[Category: Mitten | [[Category: McClellan WJ]] | ||
[[Category: Ng | [[Category: Mitten M]] | ||
[[Category: Nimmer | [[Category: Ng SC]] | ||
[[Category: Oltersdorf | [[Category: Nimmer PM]] | ||
[[Category: Oost | [[Category: Oltersdorf T]] | ||
[[Category: Park | [[Category: Oost TK]] | ||
[[Category: Petros | [[Category: Park CM]] | ||
[[Category: Rosenberg | [[Category: Petros AM]] | ||
[[Category: Shoemaker | [[Category: Rosenberg SH]] | ||
[[Category: Song | [[Category: Shoemaker AR]] | ||
[[Category: Wang | [[Category: Song X]] | ||
[[Category: Wendt | [[Category: Wang X]] | ||
[[Category: Zhang | [[Category: Wendt MD]] | ||
[[Category: Zhang H]] | |||
