1fmq: Difference between revisions

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[[Image:1fmq.gif|left|200px]]


{{Structure
==Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG==
|PDB= 1fmq |SIZE=350|CAPTION= <scene name='initialview01'>1fmq</scene>, resolution 2.&Aring;
<StructureSection load='1fmq' size='340' side='right'caption='[[1fmq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=D34:2,5-BIS{[4-(N-CYCLOBUTYLDIAMINOMETHYL)PHENYL]}FURAN'>D34</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
<table><tr><td colspan='2'>[[1fmq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FMQ FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D34:2,5-BIS{[4-(N-CYCLOBUTYLDIAMINOMETHYL)PHENYL]}FURAN'>D34</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fmq OCA], [https://pdbe.org/1fmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fmq RCSB], [https://www.ebi.ac.uk/pdbsum/1fmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fmq ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fmq OCA], [http://www.ebi.ac.uk/pdbsum/1fmq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fmq RCSB]</span>
__TOC__
}}
</StructureSection>
 
[[Category: Large Structures]]
'''Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG'''
[[Category: Boykin DW]]
 
[[Category: Kumar A]]
 
[[Category: Lee M]]
==Overview==
[[Category: Neidle S]]
2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.
[[Category: Simpson IJ]]
 
==About this Structure==
1FMQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA].
 
==Reference==
DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11128631 11128631]
[[Category: Protein complex]]
[[Category: Boykin, D W.]]
[[Category: Kumar, A.]]
[[Category: Lee, M.]]
[[Category: Neidle, S.]]
[[Category: Simpson, I J.]]
[[Category: dna-drug minor groove complex]]
 
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Retrieved from "https://proteopedia.org/1fmq"