2jch: Difference between revisions

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==STRUCTURAL AND MECHANISTIC BASIS OF PENICILLIN BINDING PROTEIN INHIBITION BY LACTIVICINS==
 
<StructureSection load='2jch' size='340' side='right' caption='[[2jch]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
==Structural and mechanistic basis of penicillin binding protein inhibition by lactivicins==
<StructureSection load='2jch' size='340' side='right'caption='[[2jch]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jch]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JCH FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jch]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JCH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PL7:(2E)-2-({(2S)-2-CARBOXY-2-[(PHENOXYACETYL)AMINO]ETHOXY}IMINO)PENTANEDIOIC+ACID'>PL7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bg1|2bg1]], [[2bg3|2bg3]], [[2bg4|2bg4]], [[2fff|2fff]], [[2jci|2jci]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PL7:(2E)-2-({(2S)-2-CARBOXY-2-[(PHENOXYACETYL)AMINO]ETHOXY}IMINO)PENTANEDIOIC+ACID'>PL7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jch OCA], [http://pdbe.org/2jch PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jch RCSB], [http://www.ebi.ac.uk/pdbsum/2jch PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jch OCA], [https://pdbe.org/2jch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jch RCSB], [https://www.ebi.ac.uk/pdbsum/2jch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jch ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O70038_STREE O70038_STREE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jch_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jch_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Penicillin-binding protein|Penicillin-binding protein]]
*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Strr6]]
[[Category: Large Structures]]
[[Category: Brown, T J]]
[[Category: Streptococcus pneumoniae R6]]
[[Category: Dessen, A]]
[[Category: Brown TJ]]
[[Category: Fisher, D S]]
[[Category: Dessen A]]
[[Category: Joris, B]]
[[Category: Fisher DS]]
[[Category: Luxen, A]]
[[Category: Joris B]]
[[Category: Macheboeuf, P]]
[[Category: Luxen A]]
[[Category: Schofield, C J]]
[[Category: Macheboeuf P]]
[[Category: Zervosen, A]]
[[Category: Schofield CJ]]
[[Category: Binding protein]]
[[Category: Zervosen A]]
[[Category: Cell wall]]
[[Category: Drug-binding protein]]
[[Category: Gamma lactam antibiotic]]
[[Category: Peptidoglycan]]
[[Category: Peptidoglycan synthesis multifunctional enzyme]]
Retrieved from "https://proteopedia.org/2jch"