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==Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium==
==Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium==
<StructureSection load='1jty' size='340' side='right' caption='[[1jty]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
<StructureSection load='1jty' size='340' side='right'caption='[[1jty]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1jty]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JTY FirstGlance]. <br>
<table><tr><td colspan='2'>[[1jty]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JTY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ET:ETHIDIUM'>ET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.97&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jt0|1jt0]], [[1jt6|1jt6]], [[1jtx|1jtx]], [[1jum|1jum]], [[1jup|1jup]], [[1jus|1jus]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ET:ETHIDIUM'>ET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jty OCA], [http://pdbe.org/1jty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jty RCSB], [http://www.ebi.ac.uk/pdbsum/1jty PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jty OCA], [https://pdbe.org/1jty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jty RCSB], [https://www.ebi.ac.uk/pdbsum/1jty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jty ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.  
[https://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/1jty_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/1jty_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Brennan, R G]]
[[Category: Large Structures]]
[[Category: Brown, M H]]
[[Category: Staphylococcus aureus]]
[[Category: Grkovic, S]]
[[Category: Brennan RG]]
[[Category: Miller, M C]]
[[Category: Brown MH]]
[[Category: Schumacher, M A]]
[[Category: Grkovic S]]
[[Category: Skurray, R A]]
[[Category: Miller MC]]
[[Category: Cationic lipophilic drug]]
[[Category: Schumacher MA]]
[[Category: Multidrug binding]]
[[Category: Skurray RA]]
[[Category: Multidrug recognition mechanism]]
[[Category: Qaca]]
[[Category: Qacr]]
[[Category: Repressor]]
[[Category: Transcription]]

Latest revision as of 08:46, 16 August 2023

Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium

1jty, resolution 2.97Å

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