2n9q: Difference between revisions

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'''Unreleased structure'''


The entry 2n9q is ON HOLD  until Paper Publication
==Photoswitchable G-quadruplex==
<StructureSection load='2n9q' size='340' side='right'caption='[[2n9q]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2n9q]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N9Q FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZW:4-{(E)-[4-(HYDROXYMETHYL)PHENYL]DIAZENYL}BENZYL+DIHYDROGEN+PHOSPHATE'>AZW</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n9q OCA], [https://pdbe.org/2n9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n9q RCSB], [https://www.ebi.ac.uk/pdbsum/2n9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n9q ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The ability of three different bifunctional azobenzene linkers to enable the photoreversible formation of a defined intermolecular two-tetrad G-quadruplex upon UV/Vis irradiation was investigated. Circular dichroism and NMR spectroscopic data showed the formation of G-quadruplexes with K(+) ions at room temperature in all three cases with the corresponding azobenzene linker in an E conformation. However, only the para-para-substituted azobenzene derivative enables photoswitching between a nonpolymorphic, stacked, tetramolecular G-quadruplex and an unstructured state after E-Z isomerization.


Authors: Thevarpadam, J., Bessi, I., Binas, O., Goncalves, D.P.N., Slavov, C., Jonker, H.R.A., Richter, C., Wachtveitl, J., Schwalbe, H., Heckel, A.
Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.,Thevarpadam J, Bessi I, Binas O, Goncalves DP, Slavov C, Jonker HR, Richter C, Wachtveitl J, Schwalbe H, Heckel A Angew Chem Int Ed Engl. 2016 Feb;55(8):2738-42. doi: 10.1002/anie.201510269. Epub, 2016 Jan 25. PMID:26805928<ref>PMID:26805928</ref>


Description: Photoswitchable G-quadruplex
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Wachtveitl, J]]
<div class="pdbe-citations 2n9q" style="background-color:#fffaf0;"></div>
[[Category: Jonker, H.R.A]]
== References ==
[[Category: Goncalves, D.P.N]]
<references/>
[[Category: Slavov, C]]
__TOC__
[[Category: Schwalbe, H]]
</StructureSection>
[[Category: Binas, O]]
[[Category: Large Structures]]
[[Category: Thevarpadam, J]]
[[Category: Bessi I]]
[[Category: Bessi, I]]
[[Category: Binas O]]
[[Category: Richter, C]]
[[Category: Goncalves DPN]]
[[Category: Heckel, A]]
[[Category: Heckel A]]
[[Category: Jonker HRA]]
[[Category: Richter C]]
[[Category: Schwalbe H]]
[[Category: Slavov C]]
[[Category: Thevarpadam J]]
[[Category: Wachtveitl J]]
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