2rvo: Difference between revisions

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'''Unreleased structure'''


The entry 2rvo is ON HOLD
==Solution structure of a reverse transcriptase recognition site of a LINE RNA from zebrafish==
<StructureSection load='2rvo' size='340' side='right'caption='[[2rvo]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2rvo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RVO FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rvo OCA], [https://pdbe.org/2rvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rvo RCSB], [https://www.ebi.ac.uk/pdbsum/2rvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rvo ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Long interspersed nuclear element (LINE) is known to be transposed by reverse transcription using its RNA transcript. Recognition of the 3' stem-loop of LINE RNA by its reverse transcriptase (RT) is an important step of the retrotransposition. Our previous study revealed that the second G residue (G8) in the GGAUA loop of a 17mer LINE RNA from eel, UnaL2-17, is recognized by its RT and the U residue (U10) in the same loop is required to maintain the loop structure (Baba S, Kajikawa M, Okada N, Kawai G. Solution structure of an RNA stem-loop derived from the 3' conserved region of eel LINE UnaL2. RNA 2004;10:1380-1387). ZfL2-2, a LINE from zebrafish, has the same 3' stem-loop with UnaL2 and ZfL2-1 has similar but distinct 3' stem-loop with an insertion which can form an additional stem-loop. Here, we determined the solution structure of the 34mer RT recognition site of the LINE RNA (ZfL2-1-34). It was found that ZfL2-1-34 forms a hairpin with an internal loop, the tertiary structure of which is superimposed with that of ZfL2-2. It is noted that A10 and the inserted stem-loop, starting with A12, in ZfL2-1-34 located at the positions corresponding to those of G8 and U10, respectively, in UnaL2-17. These results strongly suggest that the two LINEs share the similar recognition mechanism and the A10 in ZfL2-1-34 is the determinant recognized by its RT.


Authors: Otsu, M., Norose, N., Arai, N., Terao, R., Kajikawa, M., Okada, N., Kawai, G.
Solution structure of a reverse transcriptase recognition site of a LINE RNA from zebrafish.,Otsu M, Kajikawa M, Okada N, Kawai G J Biochem. 2017 Oct 1;162(4):279-285. doi: 10.1093/jb/mvx026. PMID:28431120<ref>PMID:28431120</ref>


Description: Solution structure of a reverse transcriptase recognition site of a LINE RNA from zebrafish
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Kawai, G]]
<div class="pdbe-citations 2rvo" style="background-color:#fffaf0;"></div>
[[Category: Arai, N]]
== References ==
[[Category: Norose, N]]
<references/>
[[Category: Otsu, M]]
__TOC__
[[Category: Okada, N]]
</StructureSection>
[[Category: Kajikawa, M]]
[[Category: Danio rerio]]
[[Category: Terao, R]]
[[Category: Large Structures]]
[[Category: Arai N]]
[[Category: Kajikawa M]]
[[Category: Kawai G]]
[[Category: Norose N]]
[[Category: Okada N]]
[[Category: Otsu M]]
[[Category: Terao R]]
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