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[[Image:1fx3.gif|left|200px]]


{{Structure
==CRYSTAL STRUCTURE OF H. INFLUENZAE SECB==
|PDB= 1fx3 |SIZE=350|CAPTION= <scene name='initialview01'>1fx3</scene>, resolution 2.50&Aring;
<StructureSection load='1fx3' size='340' side='right'caption='[[1fx3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1fx3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FX3 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fx3 OCA], [https://pdbe.org/1fx3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fx3 RCSB], [https://www.ebi.ac.uk/pdbsum/1fx3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fx3 ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fx3 OCA], [http://www.ebi.ac.uk/pdbsum/1fx3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fx3 RCSB]</span>
[https://www.uniprot.org/uniprot/SECB_HAEIN SECB_HAEIN] One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''CRYSTAL STRUCTURE OF H. INFLUENZAE SECB'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/1fx3_consurf.spt"</scriptWhenChecked>
==Overview==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
SecB is a bacterial molecular chaperone involved in mediating translocation of newly synthesized polypeptides across the cytoplasmic membrane of bacteria. The crystal structure of SecB from Haemophilus influenzae shows that the molecule is a tetramer organized as a dimer of dimers. Two long channels run along the side of the molecule. These are bounded by flexible loops and lined with conserved hydrophobic amino acids, which define a suitable environment for binding non-native polypeptides. The structure also reveals an acidic region on the top surface of the molecule, several residues of which have been implicated in binding to SecA, its downstream target.
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fx3 ConSurf].
1FX3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FX3 OCA].  
<div style="clear:both"></div>
 
__TOC__
==Reference==
</StructureSection>
Crystal structure of the bacterial protein export chaperone secB., Xu Z, Knafels JD, Yoshino K, Nat Struct Biol. 2000 Dec;7(12):1172-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11101901 11101901]
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Knafels, J D.]]
[[Category: Knafels JD]]
[[Category: Xu, Z.]]
[[Category: Xu Z]]
[[Category: Yoshino, K.]]
[[Category: Yoshino K]]
[[Category: protein trasnport]]
[[Category: translocation]]
 
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Retrieved from "https://proteopedia.org/1fx3"