Citrate Synthase: Difference between revisions

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{{BAMBED
|DATE=March 3, 2011
|OLDID=1200649
|BAMBEDDOI=10.1002/bmb.20519
}}
<StructureSection load='1cts' size='350' side='right' scene='User:Wayne_Decatur/1cts_to_2cts_(citrate_synthase)_morph_methods/Camorph/5' caption='Open conformation of citrate synthase dimer complex with citrate (PDB code [[1cts]]) and closed conformation of citrate synthase dimer complex with citrate and CoA (PDB code [[2cts]])'>
<StructureSection load='1cts' size='350' side='right' scene='User:Wayne_Decatur/1cts_to_2cts_(citrate_synthase)_morph_methods/Camorph/5' caption='Open conformation of citrate synthase dimer complex with citrate (PDB code [[1cts]]) and closed conformation of citrate synthase dimer complex with citrate and CoA (PDB code [[2cts]])'>


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*[[Krebs cycle importance]]
*[[Krebs cycle importance]]
*[[Krebs cycle overview]]
*[[Krebs cycle overview]]
*[[Krebs cycle reactions]]
*[[Citric Acid Cycle]]
*[[Krebs cycle step 1]]
*[[Glyoxylate cycle]]
'''2-methylcitrate synthase''' catabolizes propionate to succinate and pyruvate<ref>PMID:9579066</ref>.


==Structure==
==Structure==
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*<scene name='Citrate_Synthase/Cv/1'>Citrate Synthase Closed Form (Monomer)</scene> [[2cts]]
*<scene name='Citrate_Synthase/Cv/1'>Citrate Synthase Closed Form (Monomer)</scene> [[2cts]]
*<scene name='Citrate_Synthase/Cv/2'>'Citrate Synthase Open Form (Monomer)</scene> [[1cts]]
*<scene name='Citrate_Synthase/Cv/2'>'Citrate Synthase Open Form (Monomer)</scene> [[1cts]]
==3D structures of Citrate Synthase==
[[Citrate Synthase 3D structures]]
</StructureSection>  
</StructureSection>  
__NOTOC__
__NOTOC__
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[[Image:2cts plus overall reaction.png|500px|left|thumb| <span style="font-size:1.2em;">Citrate synthase 'closed' form complex with CoA and citrate ([[2cts]]) and the reaction</span>]]
[[Image:2cts plus overall reaction.png|500px|left|thumb| <span style="font-size:1.2em;">Citrate synthase 'closed' form complex with CoA and citrate ([[2cts]]) and the reaction</span>]]
{{Clear}}
{{Clear}}
==3D structures of Citrate Synthase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Citrate synthase
**[[3msu]] – CitS – ''Francisella tularensis''<br />
**[[3enj]] – CitS – Wild boar<br />
**[[2p2w]] – CitS – ''Thermotoga maritima''<br />
**[[2c6x]] – CitS residues 2-364 – ''Bacillus subtilis''<br />
**[[3l96]], [[1owc]], [[1nxe]], [[4jad]], [[4jae]] – EcCitS (mutant) – ''Eschericia coli''<br />
**[[1k3p]], [[4g6b]] – EcCitS II<br />
**[[2ibp]] – CitS – ''Pyrobaculum aerophilum''<br />
**[[1iom]], [[1ixe]] – CitS – ''Thermus thermophilus''<br />
**[[1o7x]] – CitS – ''Sulfolobus solfataricus''<br />
**[[1a59]] – CitS – ''Antarctic bacterium''<br />
**[[1aj8]] – CitS - ''Pyrococcus furiosus''<br />
**[[5csc]], [[3cts]]– cCitS – chicken<br />
**[[1cts]], [[2cts]] – pCitS - pig<br />
**[[4e6y]] – CitS – ''Vibrio vulnificus''<br />
**[[4tvm]] – MtCitS – ''Mycobacterium tuberculosis''<br />
**[[4xgh]] – CitS – ''Burkholderia thailandensis''<br />
*Citrate synthase binary complex
**[[3l97]] - EcCitS (mutant) + S-carboxymethyl-CoA<br />
**[[2r9e]] – TaCitS + citryl dethia CoA – ''Thermoplasma acidophilum''<br />
**[[6cts]] – cCitS + citryl thioether CoA<br />
**[[3l98]], [[1owb]], [[1nxg]], [[4jaf]] - EcCitS (mutant) + NADH<br />
**[[3l99]], [[4jag]] - EcCitS (mutant) + oxaloacetate<br />
**[[2ifc]] - TaCitS + oxaloacetate
*Citrate synthase ternary complex
**[[2r26]] - TaCitS + oxaloacetate + S-carboxymethyl-CoA<br />
**[[2h12]] - CitS + oxaloacetate + carboxymethyl dethia-CoA – ''Acetobacter aceti''<br />
**[[1al6]], [[1csr]], [[1css]], [[1csh]], [[1csi]] - cCitS + oxaloacetate + carboxymethyl dethia-CoA derivative<br />
**[[5cts]] - cCitS + oxaloacetate + carboxymethyl CoA<br />
**[[1amz]] - cCitS + malate + nitromethyl dethia-CoA<br />
**[[1csc]], [[2csc]], [[3csc]], [[4csc]] - cCitS + malate + carboxymethyl CoA<br />
**[[6csc]] - cCitS + citrate + trifluoroacetonyl-CoA<br />
**[[4cts]] - pCitS + oxaloacetate + S-acetonyl CoA<br />
* ATP-Citrate synthase
**[[3mwd]] – hCitS + citrate – human<br />
**[[3mwe]] – hCitS + tartrate <br />
**[[3pff]] – hCitS + tartrate + ADP<br />
* Methylcitrate synthase
**[[3hwk]] – MtMCitS <br />
**[[3tqg]] – 2-MCitS – ''Coxiella burnetii''<br />
}}


==See Also==
==See Also==
Retrieved from "https://proteopedia.org/Citrate_Synthase"