5i2m: Difference between revisions
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New page: '''Unreleased structure''' The entry 5i2m is ON HOLD Authors: Roche, S., Bressanelli, S. Description: CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACID... |
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==CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACIDIC CONFORMATION== | |||
<StructureSection load='5i2m' size='340' side='right'caption='[[5i2m]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5i2m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vesicular_stomatitis_Indiana_virus_strain_Mudd-Summers Vesicular stomatitis Indiana virus strain Mudd-Summers]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmz 2cmz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I2M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2m OCA], [https://pdbe.org/5i2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i2m RCSB], [https://www.ebi.ac.uk/pdbsum/5i2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2m ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/VGLG_VSIVM VGLG_VSIVM] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The vesicular stomatitis virus has an atypical membrane fusion glycoprotein (G) exhibiting a pH-dependent equilibrium between two forms at the virus surface. Membrane fusion is triggered during the transition from the high- to low-pH form. The structure of G in its low-pH form shows the classic hairpin conformation observed in all other fusion proteins in their postfusion conformation, in spite of a novel fold combining features of fusion proteins from classes I and II. The structure provides a framework for understanding the reversibility of the G conformational change. Unexpectedly, G is homologous to gB of herpesviruses, which raises important questions on viral evolution. | |||
Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G.,Roche S, Bressanelli S, Rey FA, Gaudin Y Science. 2006 Jul 14;313(5784):187-91. PMID:16840692<ref>PMID:16840692</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Bressanelli | <div class="pdbe-citations 5i2m" style="background-color:#fffaf0;"></div> | ||
[[Category: Roche | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Vesicular stomatitis Indiana virus strain Mudd-Summers]] | |||
[[Category: Bressanelli S]] | |||
[[Category: Roche S]] | |||
Latest revision as of 08:21, 23 August 2023
CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACIDIC CONFORMATION
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