5e0s: Difference between revisions

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{{Large structure}}
 
==crystal structure of the active form of the proteolytic complex clpP1 and clpP2==
==crystal structure of the active form of the proteolytic complex clpP1 and clpP2==
<StructureSection load='5e0s' size='340' side='right' caption='[[5e0s]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='5e0s' size='340' side='right'caption='[[5e0s]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5e0s]] is a 28 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E0S FirstGlance]. <br>
<table><tr><td colspan='2'>[[5e0s]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CDC1551 Mycobacterium tuberculosis CDC1551]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E0S FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0s OCA], [http://pdbe.org/5e0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e0s RCSB], [http://www.ebi.ac.uk/pdbsum/5e0s PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0s OCA], [https://pdbe.org/5e0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e0s RCSB], [https://www.ebi.ac.uk/pdbsum/5e0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e0s ProSAT]</span></td></tr>
</table>
</table>
{{Large structure}}
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CLPP2_MYCTO CLPP2_MYCTO]] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.[HAMAP-Rule:MF_00444] [[http://www.uniprot.org/uniprot/CLPP1_MYCTO CLPP1_MYCTO]] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.[HAMAP-Rule:MF_00444]  
[https://www.uniprot.org/uniprot/CLPP2_MYCTU CLPP2_MYCTU] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). Degrades anti-sigma-D factor RsdA when present in a complex with ClpP1 and ClpX. Degrades anti-sigma-E factor RseA in the presence of ClpC1. Does not seem to act on anti-sigma-L factor RslA.[HAMAP-Rule:MF_00444]<ref>PMID:20025669</ref> <ref>PMID:23314154</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5e0s" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5e0s" style="background-color:#fffaf0;"></div>
==See Also==
*[[Clp protease 3D structures|Clp protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Endopeptidase Clp]]
[[Category: Large Structures]]
[[Category: LI, M]]
[[Category: Mycobacterium tuberculosis CDC1551]]
[[Category: Maurizi, M]]
[[Category: LI M]]
[[Category: Wlodawer, A]]
[[Category: Maurizi M]]
[[Category: Hydrolase]]
[[Category: Wlodawer A]]
Retrieved from "https://proteopedia.org/5e0s"