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==Crystal Structure of Diels-Alderase PyrI4 in complex with its product==
==Crystal Structure of Diels-Alderase PyrI4 in complex with its product==
<StructureSection load='5bu3' size='340' side='right' caption='[[5bu3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5bu3' size='340' side='right'caption='[[5bu3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5bu3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BU3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5bu3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_rugosporus Streptomyces rugosporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BU3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4W9:(4S,4aS,6aS,8R,9R,10aR,13R,14aS,18aR,18bR)-9-ethyl-4,8,19-trihydroxy-10a,12,13,18a-tetramethyl-2,3,4,4a,5,6,6a,7,8,9,10,10a,13,14,18a,18b-hexadecahydro-1H-14a,17-(metheno)benzo[b]naphtho[2,1-h]azacyclododecine-16,18(15H,17H)-dione'>4W9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.897&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5btu|5btu]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4W9:(4S,4aS,6aS,8R,9R,10aR,13R,14aS,18aR,18bR)-9-ethyl-4,8,19-trihydroxy-10a,12,13,18a-tetramethyl-2,3,4,4a,5,6,6a,7,8,9,10,10a,13,14,18a,18b-hexadecahydro-1H-14a,17-(metheno)benzo[b]naphtho[2,1-h]azacyclododecine-16,18(15H,17H)-dione'>4W9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bu3 OCA], [http://pdbe.org/5bu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bu3 RCSB], [http://www.ebi.ac.uk/pdbsum/5bu3 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bu3 OCA], [https://pdbe.org/5bu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bu3 RCSB], [https://www.ebi.ac.uk/pdbsum/5bu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bu3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYRI4_STRRG PYRI4_STRRG] Involved in the biosynthesis of the spirotetramate antibiotics pyrroindomycins. Catalyzes the intramolecular cyclization forming the spiro-conjugate moiety in pyrroindomycins, via an exo-selective [4+2] cycloaddition reaction.<ref>PMID:25730548</ref> <ref>PMID:26877021</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Guo, Y]]
[[Category: Large Structures]]
[[Category: Liu, J]]
[[Category: Streptomyces rugosporus]]
[[Category: Pan, L]]
[[Category: Guo Y]]
[[Category: Complex]]
[[Category: Liu J]]
[[Category: Diels-alderase]]
[[Category: Pan L]]
[[Category: Lyase]]
Retrieved from "https://proteopedia.org/5bu3"