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| <StructureSection load='2wa5' size='350' side='right' scene='' caption='Human Filamin B actin-binding domain complex with sulfate and carbonate (PDB code [[2wa5]]) '> | | <StructureSection load='2wa5' size='350' side='right' scene='' caption='Human Filamin B actin-binding domain complex with sulfate and carbonate (PDB code [[2wa5]]) '> |
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| | __TOC__ |
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| == Function == | | == Function == |
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| Mutations in FLNA cause frontometaphyseal dysplasia, intestinal pseudo-obstruction, Melnick-Needles syndrome, otopalatodigital syndrome and periventricular heterotopia. Mutations in FLNAB cause boomerang dysplasia<ref>PMID:25614868</ref>. | | Mutations in FLNA cause frontometaphyseal dysplasia, intestinal pseudo-obstruction, Melnick-Needles syndrome, otopalatodigital syndrome and periventricular heterotopia. Mutations in FLNAB cause boomerang dysplasia<ref>PMID:25614868</ref>. |
| </StructureSection>
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| ==3D structures of filamin== | | ==3D structures of filamin== |
| | [[Filamin 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| * Filamin A
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| **[[3isw]] – hFLNA repeat 21+CFTR peptide – human<br />
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| **[[3rgh]] - hFLNA repeat 10<br />
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| **[[2wfn]], [[3hop]], [[3hor]] – hFLNA ABD<br />
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| **[[3hoc]] – hFLNA ABD (mutant)<br />
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| **[[4m9p]] - hFLNA domains 3-5<br />
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| **[[2aav]] - hFLNA domain 17 – NMR<br />
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| **[[2bp3]] - hFLNA domain 17+GPIB peptide<br />
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| **[[2k7p]] – hFLNA domains 16-17<br />
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| **[[2k7q]] - hFLNA domains 18-19<br />
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| **[[2j3s]] - hFLNA domains 19-21<br />
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| **[[2w0p]] - hFLNA domain 21+migfilin peptide<br />
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| **[[2jf1]], [[2brq]] - hFLNA domain 21+integrin peptide<br />
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| **[[2k3t]] - hFLNA domain 23 – NMR<br />
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| **[[3cnk]] - hFLNA DD<br />
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| * Filamin B
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| **[[2wa5]], [[3fer]] - hFLNB ABD<br />
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| **[[2wa6]], [[2wa7]], [[4b7l]] - hFLNB ABD (mutant)<br />
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| **[[2di9]], [[2dia]], [[2dib]], [[2dic]], [[2dj4]], [[2e9j]], [[2dmb]], [[2ee9]], [[2ee7]], [[2dmc]], [[2di8]], [[2dlg]], [[2e9i]], [[2ee6]], [[2eeb]], [[2eec]], [[2eed]] - hFLNB domains 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 20, 21, 22, 23, 24 – NMR<br />
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| **[[2eea]] - hFLNB domain 17 – NMR<br />
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| * Filamin C
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| **[[2k9u]] – hFLNC+migfilin peptide<br />
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| **[[2d7m]], [[2d7n]], [[2d7o]], [[2d7p]] - hFLNC domains 14, 16, 17, 22 - NMR<br />
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| **[[2nqc]] - hFLNC domain 21<br />
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| **[[2d7q]] - hFLNC domain 23 – NMR<br />
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| **[[3v8o]] - hFLNC domains 4,5 <br />
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| **[[4mgx]] - hFLNC domains 4,5 + platelet glycoprotein peptide<br />
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| **[[1v05]] - hFLNC DD<br />
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| * Other Filamins
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| **[[1wlh]], [[1qfh]] – FLN rod domain – ''Dictyostelium discoideum''<br />
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| }}
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| ==References== | | ==References== |
| <references /> | | <references /> |
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |
