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==MAGE-A3 reactive TCR in complex with MAGE-A3 in HLA-A1==
==MAGE-A3 reactive TCR in complex with MAGE-A3 in HLA-A1==
<StructureSection load='5brz' size='340' side='right' caption='[[5brz]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
<StructureSection load='5brz' size='340' side='right'caption='[[5brz]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5brz]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BRZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5brz]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BRZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bs0|5bs0]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5brz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5brz OCA], [http://pdbe.org/5brz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5brz RCSB], [http://www.ebi.ac.uk/pdbsum/5brz PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5brz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5brz OCA], [https://pdbe.org/5brz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5brz RCSB], [https://www.ebi.ac.uk/pdbsum/5brz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5brz ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/1A01_HUMAN 1A01_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.  
[https://www.uniprot.org/uniprot/MAGA3_HUMAN MAGA3_HUMAN] Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.<ref>PMID:20864041</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5brz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5brz" style="background-color:#fffaf0;"></div>
==See Also==
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC I 3D structures|MHC I 3D structures]]
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bossi, G]]
[[Category: Homo sapiens]]
[[Category: Cole, D K]]
[[Category: Large Structures]]
[[Category: Donnellan, Z]]
[[Category: Bossi G]]
[[Category: Dukes, J]]
[[Category: Cole DK]]
[[Category: Hassan, N]]
[[Category: Donnellan Z]]
[[Category: Hickman, E]]
[[Category: Dukes J]]
[[Category: Jakobsen, B K]]
[[Category: Hassan N]]
[[Category: LeProvost, G]]
[[Category: Hickman E]]
[[Category: LomaX, M]]
[[Category: Jakobsen BK]]
[[Category: Mahon, T]]
[[Category: LeProvost G]]
[[Category: Oates, J]]
[[Category: LomaX M]]
[[Category: Raman, M C.C]]
[[Category: Mahon T]]
[[Category: Rizkallah, P J]]
[[Category: Oates J]]
[[Category: Sami, M]]
[[Category: Raman MCC]]
[[Category: Simmons, R]]
[[Category: Rizkallah PJ]]
[[Category: Vuidepot, A]]
[[Category: Sami M]]
[[Category: Immune system]]
[[Category: Simmons R]]
[[Category: Immuno pmhc tcr mage]]
[[Category: Vuidepot A]]
Retrieved from "https://proteopedia.org/5brz"