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==Structure of Sugar Binding Protein Pneumolysin==
==Structure of Sugar Binding Protein Pneumolysin==
<StructureSection load='4zgh' size='340' side='right' caption='[[4zgh]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='4zgh' size='340' side='right'caption='[[4zgh]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zgh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZGH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zgh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_D39 Streptococcus pneumoniae D39]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZGH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AUC:GOLD+(I)+CYANIDE+ION'>AUC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgh OCA], [http://pdbe.org/4zgh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zgh RCSB], [http://www.ebi.ac.uk/pdbsum/4zgh PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AUC:GOLD+(I)+CYANIDE+ION'>AUC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgh OCA], [https://pdbe.org/4zgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zgh RCSB], [https://www.ebi.ac.uk/pdbsum/4zgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zgh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TACY_STRP2 TACY_STRP2]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).  
[https://www.uniprot.org/uniprot/TACY_STRP2 TACY_STRP2] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4zgh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4zgh" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cytolysin 3D structures|Cytolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Feil, S C]]
[[Category: Large Structures]]
[[Category: Morton, C]]
[[Category: Streptococcus pneumoniae D39]]
[[Category: Parker, M W]]
[[Category: Feil SC]]
[[Category: Beta-cft]]
[[Category: Morton C]]
[[Category: Sugar binding protein]]
[[Category: Parker MW]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/4zgh"