Homocitrate synthase: Difference between revisions
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<StructureSection load='3ivt' size='400' side='right' scene='46/465446/Cv/1' caption='Fission yeast homocitrate synthase Lys4 dimer complex with 2-oxoglutarate, Na+ (purple) and Zn+2 (grey) ions [[3ivt]]'> | |||
== Function == | == Function == | ||
'''Homocitrate synthase''' (HS) participates in lysine biosynthesis and pyruvate metabolism. HS catalyzes the conversion of acetyl-CoA + H2O + 2-oxoglutarate to 2-hydroxybutane-1,2,4-tricarboxylate + CoA<ref>PMID:5836514</ref>. | '''Homocitrate synthase''' (HS) participates in lysine biosynthesis and pyruvate metabolism. HS catalyzes the conversion of acetyl-CoA + H2O + 2-oxoglutarate to 2-hydroxybutane-1,2,4-tricarboxylate + CoA<ref>PMID:5836514</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
The HS active site is located in the interior of the N-terminal TIM-barrel domain. | The HS <scene name='46/465446/Cv/7'>active site is located in the interior of the N-terminal TIM-barrel domain</scene>. | ||
*<scene name='46/465446/Cv/8'>Active site</scene>. | |||
*The <scene name='46/465446/Cv/9'>metal ion is octahedrally coordinated to the protein and to the 2-oxoglutarate</scene><ref>PMID:19776021</ref>. Water molecules shown as red spheres. | |||
</StructureSection> | |||
== 3D Structures of homocitrate synthase == | == 3D Structures of homocitrate synthase == | ||
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[[2zyf]] - TtHS + α-ketoglutarate + Mg<br /> | [[2zyf]] - TtHS + α-ketoglutarate + Mg<br /> | ||
[[2ztk]] – TtHS + homocitrate<br /> | [[2ztk]] – TtHS + homocitrate<br /> | ||
[[3a9i]] – TtHS + lysine | [[3a9i]] – TtHS + lysine<br /> | ||
[[6ktq]] - HS + -ketoglutarate + CoA – ''Sulfolobus acidocaldarius''<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
