Sandbox Reserved 1171: Difference between revisions

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== Background ==

Human G-protein coupled receptor 40 (hGPR40) is a seven helical transmembrane domain receptor for long-chain free fatty acids that slimutates [[insulin]] secretion (Srivastava). This enzyme is primarily located in the pancreatic b-cells in the islets of Langerhans, and as such, it has become a target for potential [http://www.diabetes.org/living-with-diabetes/treatment-and-care/ Type II Diabetes treatments] (Kebede). Activation of hGPR40 has been shown to both stimulate insulin secretion and decrease glucose concentration (Ma, 2016). GPR40 is a member of a group of homologous [[GPCRs]] all located on chromosome 19q13.1 including GPR41, 42, and 43.

== Structure ==

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<scene name='72/721542/Tak_binding_site/3'>Tak-875 Binding Site</scene>

[[Image:4phuBind2.png|200 px|right|thumb|Figure 2. Second proposed binding site of GPR40. By visual inspection, a second possible binding site was proposed between transmembrane helices 3, 4, and 5 on the intracellular side.]]

[[Image:4phuBind3.png|200 px|right|thumb|Figure 3. Third proposed binding site of GPR40. By visual inspection, a third possible binding site was proposed between transmembrane helices 1, 2, and 7 on the extracellular side.]]

[[Image:4phubind3.png|200 px|right|thumb|Figure 3. Third proposed binding site of GPR40. By visual inspection, a third possible binding site was proposed between transmembrane helices 1, 2, and 7 on the extracellular side.]]

Sandbox Reserved 1171: Difference between revisions

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@@ Line 4: / Line 4: @@
 == Background ==
-Human G-protein coupled receptor 40 (hGPR40) is a seven helical transmembrane domain receptor for long-chain free fatty acids that slimutates [[insulin]] secretion (Srivastava). This enzyme is primarily located in the pancreatic b-cells in the islets of Langerhans, and as such, it has become a target for potential [http://www.diabetes.org/living-with-diabetes/treatment-and-care/ Type II Diabetes treatments] (Kebede). Activation of hGPR40 has been shown to both stimulate insulin secretion and decrease glucose concentration (Ma, 2016). GPR40 is a member of a group of homologous [[GPCRs]] all located on chromosome 19q13.1 including GPR41, 42, and 43.
 == Structure ==
@@ Line 15: / Line 14: @@
 <scene name='72/721542/Tak_binding_site/3'>Tak-875 Binding Site</scene>
 [[Image:4phuBind2.png|200 px|right|thumb|Figure 2. Second proposed binding site of GPR40. By visual inspection, a second possible binding site was proposed between transmembrane helices 3, 4, and 5 on the intracellular side.]]
-[[Image:4phuBind3.png|200 px|right|thumb|Figure 3. Third proposed binding site of GPR40. By visual inspection, a third possible binding site was proposed between transmembrane helices 1, 2, and 7 on the extracellular side.]]
 [[Image:4phubind3.png|200 px|right|thumb|Figure 3. Third proposed binding site of GPR40. By visual inspection, a third possible binding site was proposed between transmembrane helices 1, 2, and 7 on the extracellular side.]]