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LPA is still in the clinical stage of testing.  So far the LPA receptors have had physiological effects on every organism that it has been tested with.  There have been studies done looking at what happens with infertility, fibrosis, pain, and cancer when they come into contact with LPA receptors ,ref name= "Chrencik"/>.  LPA receptors are commonly found in serum and saliva. <ref name= "Moolenaar"/>.   

LPA, a signaling phospholipid, that attaches to three specific G-protein-coupled receptors.  After an injury occurs LPA is released in the body.  It then will activate G-protein-coupled receptors.  Within the nervous system, LPA plays a role in the nociceptive process (nociceptive pain is a sharp pain that can come from a mild burn or twisted ankle).  The LPA signaling will activate GTPase RhoA.  Once activated Rho translocates to the plasma membrane.  Rho will activate Rho kinase (ROCK).  Mice with the deletation of LPA₁ receptors were studied to see the role that LPA signaling played in pain.  In a study done with mice, those without the LPA₁ receptor had lower levels of pain.<ref name= "Inoue"> DOI:10.1038/nm1060 </ref>.  Another use of LPA is it can help in stimulation of cell migration <ref name= "Moolenaar" </ref>.  

To look at the effects of LPA on fibrosis, there was a study done with mice <ref> PMID:18066075 </ref>.  It was seen that with targeted deletion of LPA receptors the mice would be cured from fibrosis.  Mice who had fibrosis were given LPA1 regulated LPA-induced fibroblast.  Over time the mice who had fibrosis began to have their lungs repaired.  The amount of fluid in their lungs decreased.