Isopenicillin N synthase: Difference between revisions
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<StructureSection load='1blz' size=' | <StructureSection load='1blz' size='350' side='right' scene='52/525170/Cv/1' caption='Isopenicilln N synthase complex with ACV and NO, [[1blz]]'> | ||
== Function == | == Function == | ||
| Line 5: | Line 5: | ||
== Structural highlights == | == Structural highlights == | ||
IPNS active site contains Fe+2 and the substrate ACV. | IPNS <scene name='52/525170/Cv/7'>active site contains Fe+2 and the substrate ACV</scene>. The <scene name='52/525170/Cv/8'>Fe+2 ion is hexacoordinated to 3 IPNS side chains, one water molecule, the ACV thiolate moiety and NO</scene><ref>PMID:9194566</ref>. Water molecules shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of isopenicillin N synthase== | ==3D structures of isopenicillin N synthase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*IPNS | |||
**[[8bbb]] - AnIPNS + ACV – ''Aspergillus nidulans''<br /> | |||
**[[6jyv]] – IPNS – ''Pseudomonas aeruginosa''<br /> | |||
*Fe containing IPNS | *Fe containing IPNS | ||
**[[1bk0]] - AnIPNS + ACV | **[[1bk0]], [[6y0o]], [[6zae]], [[6zaf]], [[6zag]], [[6zah]], [[6zam]] - AnIPNS + ACV + Fe <br /> | ||
**[[2bjs]] - AnIPNS (mutant) + ACV<br /> | **[[2bjs]], [[7zoe]], [[8alj]], [[8bb9]], [[8bba]], [[8bbd]], [[8bsv]], [[8bsy]], [[8p47]], [[8ptv]] - AnIPNS (mutant) + ACV + Fe<br /> | ||
**[[ | **[[1hb1]], [[1hb2]], [[1hb3]], [[1hb4]], [[1oc1]], [[1odm]], [[1odn]], [[1qiq]], [[1qjf]], [[1uzw]], [[1w03]], [[1w05]], [[1w3v]], [[1w3x]], [[2bu9]], [[2ivi]], [[2ivj]], [[2vau]], [[2vbb]], [[2vbd]], [[2vbp]], [[2vcm]], [[2ve1]], [[2wo7]], [[2y60]], [[2y6f]], [[4bb3]], [[8p7p]], [[8py5]] - AnIPNS + ACV derivative + Fe<br /> | ||
**[[2jb4]] - AnIPNS + cyclobutanone analog<br /> | **[[8py8]], [[8py9]] - AnIPNS + ACV derivative + Fe + O2<br /> | ||
**[[2jb4]] - AnIPNS + cyclobutanone analog + Fe<br /> | |||
**[[6y0p]], [[6zao]], [[6zaq]], [[8py6]] - AnIPNS + IPN + Fe<br /> | |||
**[[8p7o]] - AnIPNS + inhibitor + Fe<br /> | |||
**[[7p3l]] - AnIPNS + substate analog + Fe<br /> | |||
**[[8p46]] - AnIPNS (mutant) + IPN + Fe<br /> | |||
**[[1qje]] - AnIPNS + IPN + ACV<br /> | **[[1qje]] - AnIPNS + IPN + ACV<br /> | ||
**[[1blz]] - AnIPNS + NO + ACV<br /> | **[[6zai]], [[6zaj]], [[6zal]], [[6zap]] - AnIPNS + O2 + ACV<br /> | ||
**[[7poy]] - AnIPNS (mutant) + NO + ACV<br /> | |||
**[[8py7]], [[8pya]] - AnIPNS (mutant) + Fe + O2 + ACV<br /> | |||
**[[7psw]], [[8ali]], [[8bbc]], [[8bsw]], [[8bsx]], [[8p48]], [[8rdb]] - AnIPNS (mutant) + Fe + ACV<br /> | |||
**[[1blz]], [[6zan]] - AnIPNS + NO + ACV<br /> | |||
**[[1obn]], [[1w04]], [[1w06]] - AnIPNS + hydroxylamine + ACV derivative<br /> | **[[1obn]], [[1w04]], [[1w06]] - AnIPNS + hydroxylamine + ACV derivative<br /> | ||
**[[3zku]], [[3zky]], [[3zoi]], [[4bb3]] - IPNS + ACV derivative – ''Emericella nidulans''<br /> | **[[3zku]], [[3zky]], [[3zoi]], [[4bb3]] - IPNS + ACV derivative – ''Emericella nidulans''<br /> | ||
* | *Other metal containing IPNS | ||
**[[1ips]] – AnIPNS + Mn<br /> | |||
**[[6zw8]] - AnIPNS + ACV + Cd<br /> | |||
**[[8a4g]] - AnIPNS (mutant) + ACV + Cd<br /> | |||
**[[6zAK]] - AnIPNS + ACV + VO2<br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Latest revision as of 06:45, 8 October 2025
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3D structures of isopenicillin N synthase
Updated on 08-October-2025
