Menin: Difference between revisions
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<StructureSection load='3u86' size=' | <StructureSection load='3u86' size='450' side='right' caption='Structure of human menin (magenta) complex with Jun-D peptide (green) (PDB code [[3u86]]).' scene='59/591941/Cv/1'> | ||
== Function == | == Function == | ||
'''Menin''' (Men) is a putative tumor suppressor. Men possesses two functional nuclear localization signals and inhibits transcriptional activation by JunD<ref>PMID:11524225</ref>. | '''Menin''' or '''multiple endocrine neoplasia I''' (Men) is a putative tumor suppressor. Men possesses two functional nuclear localization signals and inhibits transcriptional activation by JunD<ref>PMID:11524225</ref>. | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
Jun-D interacts with Men in a deep pocket via 8 residues mainly<ref>PMID:22327296</ref>. | <scene name='59/591941/Cv/3'>Jun-D interacts with Men in a deep pocket via 8 residues mainly</scene><ref>PMID:22327296</ref>. | ||
==3D structures of menin== | ==3D structures of menin== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[3u84]] – hMen – human<br /> | [[3u84]], [[7o9t]] – hMen – human<br /> | ||
[[4og3]], [[4og4]], [[4og5]], [[4og6]], [[4og7]], [[4og8]] – hMen + inhibitor<br /> | [[9c4w]], [[9c4x]], [[9c4y]], [[9c4z]] – hMen (mutant) <br / | ||
[[4gpq]], [[4gq3]], [[4gq4]], [[4x5y]], [[4x5z]] – hMen (mutant) + inhibitor<br /> | [[4og3]], [[4og4]], [[4og5]], [[4og6]], [[4og7]], [[4og8]], [[6b41]], [[6bxh]], [[6bxy]], [[6by8]], [[6e1a]], [[6mnh]], [[6o5i]], [[6s2k]], [[6wnh]], [[7m4t]], [[7o9x]], [[7o9z]], [[7oa9]], [[9c92]], [[9c93]], [[9c94]] – hMen + inhibitor<br /> | ||
[[4i80]] – hMen + peptide inhibitor<br /> | [[4gpq]], [[4gq3]], [[4gq4]], [[4x5y]], [[4x5z]], [[5db0]], [[5db1]], [[5db2]], [[5db3]], [[5dd9]], [[5dda]], [[5ddb]], [[5ddc]], [[5ddd]], [[5dde]], [[5ddf]], [[6pkc]], [[7uj4]], [[8e90]], [[8ig0]] – hMen (mutant) + inhibitor<br /> | ||
[[8va6]], [[9z4x]] – hMen + drug<br /> | |||
[[8va5]] – hMen (mutant) + drug<br /> | |||
[[4i80]], [[6opj]] – hMen + peptide inhibitor<br /> | |||
[[3u85]] – hMen + histone-lysine N-methyltransferase Mll peptide<br /> | [[3u85]] – hMen + histone-lysine N-methyltransferase Mll peptide<br /> | ||
[[4gq6]] – hMen (mutant) + histone-lysine N-methyltransferase Mll peptide<br /> | [[4gq6]], [[9c4s]], [[9c4t]], [[9c4u]], [[9c4v]] – hMen (mutant) + histone-lysine N-methyltransferase Mll peptide<br /> | ||
[[3u86]] – hMen + JunD peptide<br /> | [[3u86]] – hMen + JunD peptide<br /> | ||
[[3u88]] – hMen + histone-lysine N-methyltransferase Mll + lens epithelium-derived growth factor<br /> | [[3u88]] – hMen + histone-lysine N-methyltransferase Mll + lens epithelium-derived growth factor<br /> | ||
[[8gpn]] – hMen in nucleosome – Cryo EM<br /> | |||
== References == | == References == | ||
