Neuroligin: Difference between revisions

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[[Image:3be8a.png|left|200px|thumb|Crystal Structure of human Neuroligin [[3be8]]]]
<StructureSection load='' size='350' side='right' scene='42/422448/Cv/2' caption='Dimer of two mouse neuroligin-1 cholinesterase-like domains (magenta and cyan) in complex with two neurexin-beta1 LNS6 domains (salmon and yellow) and Ca+2 ions (green) [[3b3q]]'>
{{STRUCTURE_3b3q|  PDB=3b3q  | SIZE=350| SCENE= |right|CAPTION=Dimer of two mouse neuroligin-1 cholinesterase-like domains (grey and green) in complex with two neurexin-beta1 LNS6 domains (pink and cyan) and Ca+2 ions (green) [[3b3q]] }}
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 




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[[Neuroligin-Neurexin Interaction]]
[[Neuroligin-Neurexin Interaction]]
*'''NLGN-1''' regulates spines and synaptic plasticity<ref>PMID:26880202</ref>. <br />
*'''NLGN-2''' is localized to inhibitory synapses<ref>PMID:15540461</ref>. <br />
*'''NLGN-3''' is a synapse organizer which shapes normal function and autism disorder<ref>PMID:17897391</ref>. <br />
*'''NLGN-4''' is localized to glyceric  post-synapses and regulates retina inhibition<ref>PMID:21282647</ref>. <br />


== Disease ==
== Disease ==
Mutations in NLGN 4 are associated with autism and mental retardation<ref>PMID:19726642</ref>.


== Structural insights ==
The <scene name='42/422448/Cv/5'>NLGN-NRXN complex involves the octahedrally coordinated Ca+2 ion</scene><ref>PMID:18084303</ref>. Water molecules are shown as red spheres.
</StructureSection>
== 3D Structures of Neuroligin ==  
== 3D Structures of Neuroligin ==  


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* Neuroligin
* Neuroligin


**[[5ojk]] -  hNLGN-1 cholinesterase domain - human<br />
**[[3bix]] -  rNLGN-1 cholinesterase domain - rat<br />
**[[8gs4]] -  hNLGN-2 – Cryo EM<br />
**[[3bl8]] -  mNLGN-2 cholinesterase domain – mouse<br />
**[[3bl8]] -  mNLGN-2 cholinesterase domain – mouse<br />
**[[7cee]] - mNLGN-3 cholinesterase domain<br />
**[[3be8]] -  hNLGN-4 cholinesterase domain – human<br />
**[[3be8]] -  hNLGN-4 cholinesterase domain – human<br />
**[[3bix]] -  rNLGN-1 cholinesterase domain - rat<br />


* Neuroligin+neurexin
* Neuroligin+neurexin
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**[[3biw]] -  rNLGN-1 cholinesterase domain+NRXN-1β LNS domain<br />
**[[3biw]] -  rNLGN-1 cholinesterase domain+NRXN-1β LNS domain<br />
**[[3vkf]] - rNLGN-1 cholinesterase domain + bNRXN-1β LNS domain
**[[3vkf]] - rNLGN-1 cholinesterase domain + bNRXN-1β LNS domain
*NLGN other complexes
**[[5oj6]] -  rNLGN-1 cholinesterase domain + MDGA1<br />
**[[9fan]], [[9far]] -  hNLGN-2 TMD domain 674-696 + GABA receptor gamma2 subunit + GARLH4 – Cryo EM<br />
**[[9faj]], [[9fam]], [[9fap]], [[9faq]], [[9fau]], [[9fav]], [[9faw]], [[9fax]] -  hNLGN-2 TMD domain + GABA receptor + GARLH4 + megabody – Cryo EM<br />
**[[9fat]] -  hNLGN-2 TMD domain + GABA receptor + GARLH4 + megabody + pregnenolone – Cryo EM<br />
**[[9fak]] -  hNLGN-2 TMD domain + GABA receptor + GARLH4 + megabody + GABA – Cryo EM<br />
**[[5v5v]] -  rNLGN-2 cholinesterase domain + MDGA1<br />
**[[5xeq]] -  rNLGN-2 cholinesterase domain (mutant) + MDGA1<br />
**[[7ceg]] -  mNLGN-3 cholinesterase domain + PTP d<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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