Neuropilin: Difference between revisions
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<StructureSection load='' size='350' side='right' scene='46/466529/Cv/1' caption='Human glycosylated neuropilin-1 domains A2,B1,B2 complex with ethylene glycol and Ca+2 ion (green) [[2qqm]]'> | |||
== Function == | == Function == | ||
'''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins<ref>PMID:12613542</ref>. There are 2 classes of NRP – NRP-1 and NRP-2.<br /> | '''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins<ref>PMID:12613542</ref>. There are 2 classes of NRP – NRP-1 and NRP-2.<br /> | ||
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NRP are highly expressed in human neoplasms<ref>PMID:18363553</ref>. | NRP are highly expressed in human neoplasms<ref>PMID:18363553</ref>. | ||
== Structural highlights == | |||
NPR structure contains the extracellular domains A1, A2 which bind semaphorin; B1, B2 which bind VEGF and C which is the dimerization region. | |||
*<scene name='46/466529/Cv/3'>Ca coordination site</scene>. Water molecule are shown as red sphere. | |||
</StructureSection> | |||
== 3D Structures of Neuropilin == | == 3D Structures of Neuropilin == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*NRP-1 | *NRP-1; Domains - B1 273-427, MAM 628-813, A2B1B2 141-586 | ||
**[[3i97]] - hNRP-1 | **[[1kex]], [[2qqi]] – hNRP-1 B1 domain – human<br /> | ||
**[[4rn5]] – hNRP-1 B1 domain<br /> | |||
**[[7o1n]] – hNRP-1 B1 domain (mutant)<br /> | |||
**[[5l73]] – hNRP-1 MAM domain<br /> | |||
**[[2qqm]] - hNRP-1 A2+B1+B2 domains<br /> | |||
**[[4deq]] - hNRP-1 B1 domain + VEGF-A heparin-binding domain<br /> | |||
**[[6tkk]] - hNRP-1 B1 domain + VEGF-A peptide<br /> | |||
**[[7p5u]] - hNRP-1 B1 domain + VEGF-B peptide<br /> | |||
**[[7jjc]] - hNRP-1 B1 domain + SARS-CoV-2 peptide<br /> | |||
**[[2qqn]] - hNRP-1 B1 domain + VEGF-blocking antibody | |||
**[[5c7g]] – hNRP-1 B1 domain + bicine<br /> | |||
**[[5ijr]], [[5iyy]], [[5j1x]], [[5jgi]], [[5jgq]], [[5jhk]] – hNRP-1 B1 domain + arginine derivative<br /> | |||
**[[3i97]], [[6fmc]], [[6fmf]] - hNRP-1 B1 domains + inhibitor | |||
**[[8pfe]] - hNRP-1 B1 domain + peptide | |||
**[[9f6b]] - hNRP-1 B1B2 domains + quinoline inhibitor | |||
**[[8c5g]] - hNRP-1 B1B2 domains + chlorotoxin | |||
**[[9eou]] - hNRP-1 B1B2 domains + peptide | |||
**[[2orx]] – rNRP-1 | **[[2orx]] – rNRP-1 B domains – rat | ||
**[[2orz]] – rNRP-1 + tuftsin peptide<br /> | **[[2orz]] – rNRP-1 B domains + tuftsin peptide<br /> | ||
**[[4gz9]] - mNRP-1 | **[[4gz9]] - mNRP-1 – mouse<br /> | ||
**[[4gza]] - mNRP-1 | **[[4gza]] - mNRP-1 + plexin A2 + semaphorin 3A<br /> | ||
**[[7m0r]] – mNRP-1 + Semaphorin 3A + plexin A4 – Cryo EM<br /> | |||
*NRP-2 | *NRP-2; Domains - CUB 27-145; A2 145-275; B1 275-430; B2 431-595 | ||
**[[ | **[[7t4s]] – hNRP-2 + Herpes virus envelope + antibody – Cryo EM<br /> | ||
**[[4qdr]] - hNRP-2 | **[[4qdq]], [[4qds]], [[2qqj]] - hNRP-2 B1+B2 domains<br /> | ||
**[[2qqo]] - hNRP-2 | **[[5dq0]] – hNRP-2 B1 domain<br /> | ||
**[[4qdr]] - hNRP-2 B1+B2 domain (mutant)<br /> | |||
**[[2qqk]], [[2qql]] - hNRP-2 | **[[2qqo]] - hNRP-2 A2+B1+B2 domains<br /> | ||
**[[2qqk]], [[2qql]] - hNRP-2 A2+B1+B2 domains + semaphorin-blocking antibody<br /> | |||
**[[5dn2]], [[6tdb]], [[6tjt]] – hNRP-2 B1 domain + VEGF-A C terminal<br /> | |||
**[[6gh8]] – hNRP-2 CUB domain 1 + Gp1<br /> | |||
**[[8ivw]] – hNRP-2 + antibody<br /> | |||
**[[7m22]] – mNRP-2 + cytomegalovirus – Cryo EM<br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
