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==Fc Design 7.7 B chain homodimer T366V/K409I==
==Fc Design 7.7 B chain homodimer T366V/K409I==
<StructureSection load='5dvk' size='340' side='right' caption='[[5dvk]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5dvk' size='340' side='right'caption='[[5dvk]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5dvk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DVK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DVK FirstGlance]. <br>
<table><tr><td colspan='2'>[[5dvk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DVK FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5di8|5di8]], [[5dj0|5dj0]], [[5dj2|5dj2]], [[5dj6|5dj6]], [[5dj8|5dj8]], [[5dja|5dja]], [[5djc|5djc]], [[5djd|5djd]], [[5djx|5djx]], [[5djy|5djy]], [[5djz|5djz]], [[5dk0|5dk0]], [[5dk2|5dk2]], [[5dvl|5dvl]], [[5dvm|5dvm]], [[5dvn|5dvn]], [[5dvo|5dvo]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dvk OCA], [http://pdbe.org/5dvk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dvk RCSB], [http://www.ebi.ac.uk/pdbsum/5dvk PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dvk OCA], [https://pdbe.org/5dvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dvk RCSB], [https://www.ebi.ac.uk/pdbsum/5dvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dvk ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.  
[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
== Function ==
[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aldaz, H]]
[[Category: Homo sapiens]]
[[Category: Atwell, S]]
[[Category: Large Structures]]
[[Category: Chamberlain, A K]]
[[Category: Synthetic construct]]
[[Category: Demarest, S J]]
[[Category: Aldaz H]]
[[Category: Dhanani, S H]]
[[Category: Atwell S]]
[[Category: Fitchett, J R]]
[[Category: Chamberlain AK]]
[[Category: Froning, K J]]
[[Category: Demarest SJ]]
[[Category: Gutierrez, B]]
[[Category: Dhanani SH]]
[[Category: Hendle, J]]
[[Category: Fitchett JR]]
[[Category: Huang, F]]
[[Category: Froning KJ]]
[[Category: Kuhlman, B]]
[[Category: Gutierrez B]]
[[Category: Leaver-Fay, A]]
[[Category: Hendle J]]
[[Category: Lu, F]]
[[Category: Huang F]]
[[Category: Pustilnik, A]]
[[Category: Kuhlman B]]
[[Category: Yuan, R]]
[[Category: Leaver-Fay A]]
[[Category: Fc]]
[[Category: Lu F]]
[[Category: Head-to-tail homodimer]]
[[Category: Pustilnik A]]
[[Category: Immune system]]
[[Category: Yuan R]]
[[Category: Immunoglobulin]]
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